Cdh1-APC controls axonal growth and patterning in the mammalian brain.
The anaphase-promoting complex (APC) is highly expressed in postmitotic neurons, but its function in the nervous system was previously unknown. We report that the inhibition of Cdh1-APC in primary neurons specifically enhanced axonal growth. Cdh1 knockdown in cerebellar slice overlay assays and in the developing rat cerebellum in vivo revealed cell-autonomous abnormalities in layer-specific growth of granule neuron axons and parallel fiber patterning. Cdh1 RNA interference in neurons was also found to override the inhibitory influence of myelin on axonal growth. Thus, Cdh1-APC appears to play a role in regulating axonal growth and patterning in the developing brain that may also limit the growth of injured axons in the adult brain.[1]References
- Cdh1-APC controls axonal growth and patterning in the mammalian brain. Konishi, Y., Stegmüller, J., Matsuda, T., Bonni, S., Bonni, A. Science (2004) [Pubmed]
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