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Gene Review

Cdh1  -  cadherin 1

Rattus norvegicus

Synonyms: Cadherin-1, E-cadherin, Epithelial cadherin, Uvomorulin
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Disease relevance of Cdh1


High impact information on Cdh1


Chemical compound and disease context of Cdh1


Biological context of Cdh1


Anatomical context of Cdh1


Associations of Cdh1 with chemical compounds

  • Using a semiquantitative RT-PCR assay, messenger RNA expression was determined for each cadherin superfamily member during a postnatal developmental time-course and following ablation of specific testis cell types by ethanedimethanesulfonate, methoxyacetic acid, and 2,5-hexanedione [20].
  • These data suggest that PTPmu may be one of the enzymes that regulates the dynamic tyrosine phosphorylation, and thus function, of the cadherin/catenin complex in vivo [21].
  • Greater than 80% of the cadherin in the cell is cleared from Triton X-100 lysates of MvLu cells after immunoprecipitation with antibodies to PTPmu; however, the complex is dissociated when lysates are prepared in more stringent, SDS-containing RIPA buffer [21].
  • The cytoplasmic domain of E-cadherin contains two putative basal-lateral sorting motifs, which are homologous to sorting signals in the low density lipoprotein receptor, but an alanine scan across tyrosine residues in these motifs did not affect the fidelity of newly synthesized E-cadherin delivery to the basal-lateral membrane of MDCK cells [22].
  • Its cDNA encodes an integral membrane protein that contains four cadherin-like ectodomains and a thrice tandemly repeated region enriched in threonine, serine, and proline, similar to those of mucins [23].

Physical interactions of Cdh1


Regulatory relationships of Cdh1


Other interactions of Cdh1


Analytical, diagnostic and therapeutic context of Cdh1


  1. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Møller, C.J., Christgau, S., Williamson, M.R., Madsen, O.D., Niu, Z.P., Bock, E., Baekkeskov, S. Mol. Endocrinol. (1992) [Pubmed]
  2. Cyclosporin-induced downregulation of the expression of E-cadherin during proliferation of edentulous gingival epithelium in rats. Tu, H.P., Chen, Y.T., Shieh, Y.S., Chin, Y.T., Huang, R.Y., Yang, S.F., Gau, C.H., Fu, E. J. Periodontol. (2006) [Pubmed]
  3. E-cadherin expression is inversely proportional to tumor size in experimental liver metastases. Karube, H., Masuda, H., Ishii, Y., Takayama, T. J. Surg. Res. (2002) [Pubmed]
  4. Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. Weis, S., Shintani, S., Weber, A., Kirchmair, R., Wood, M., Cravens, A., McSharry, H., Iwakura, A., Yoon, Y.S., Himes, N., Burstein, D., Doukas, J., Soll, R., Losordo, D., Cheresh, D. J. Clin. Invest. (2004) [Pubmed]
  5. Dissociation and reassembly of adherens junctions during experimental acute pancreatitis. Lerch, M.M., Lutz, M.P., Weidenbach, H., Müller-Pillasch, F., Gress, T.M., Leser, J., Adler, G. Gastroenterology (1997) [Pubmed]
  6. Cadherin regulates dendritic spine morphogenesis. Togashi, H., Abe, K., Mizoguchi, A., Takaoka, K., Chisaka, O., Takeichi, M. Neuron (2002) [Pubmed]
  7. Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). Oldfield, M.D., Bach, L.A., Forbes, J.M., Nikolic-Paterson, D., McRobert, A., Thallas, V., Atkins, R.C., Osicka, T., Jerums, G., Cooper, M.E. J. Clin. Invest. (2001) [Pubmed]
  8. A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation. Tang, L., Hung, C.P., Schuman, E.M. Neuron (1998) [Pubmed]
  9. Localization of neural cell adhesion molecule and pan-cadherin immunoreactivity in intrauterine growth-retarded newborn rat kidneys. Filiz, S., Dalcik, C., Filiz, T.M., Dalcik, H. Appl. Immunohistochem. Mol. Morphol. (2003) [Pubmed]
  10. Aberrant DNA methylation of E-cadherin and p16 genes in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. Kato, A., Shimizu, K., Shimoichi, Y., Fujii, H., Honoki, K., Tsujiuchi, T. Mol. Carcinog. (2006) [Pubmed]
  11. Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin. Wali, R.K., Khare, S., Tretiakova, M., Cohen, G., Nguyen, L., Hart, J., Wang, J., Wen, M., Ramaswamy, A., Joseph, L., Sitrin, M., Brasitus, T., Bissonnette, M. Cancer Epidemiol. Biomarkers Prev. (2002) [Pubmed]
  12. Cadherin and catenin staining in podocytes in development and puromycin aminonucleoside nephrosis. Yaoita, E., Sato, N., Yoshida, Y., Nameta, M., Yamamoto, T. Nephrol. Dial. Transplant. (2002) [Pubmed]
  13. The loss of E-cadherin mRNA transcripts in rat prostatic tumors is accompanied by increased expression of mRNA transcripts encoding fibronectin and its receptor. MacCalman, C.D., Brodt, P., Doublet, J.D., Jednak, R., Elhilali, M.M., Bazinet, M., Blaschuk, O.W. Clin. Exp. Metastasis (1994) [Pubmed]
  14. Cdh1-APC controls axonal growth and patterning in the mammalian brain. Konishi, Y., Stegmüller, J., Matsuda, T., Bonni, S., Bonni, A. Science (2004) [Pubmed]
  15. Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. Fasen, K., Beck, H., Elger, C.E., Lie, A.A. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  16. Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. Izumi, G., Sakisaka, T., Baba, T., Tanaka, S., Morimoto, K., Takai, Y. J. Cell Biol. (2004) [Pubmed]
  17. Fast dissociation kinetics between individual E-cadherin fragments revealed by flow chamber analysis. Perret, E., Benoliel, A.M., Nassoy, P., Pierres, A., Delmas, V., Thiery, J.P., Bongrand, P., Feracci, H. EMBO J. (2002) [Pubmed]
  18. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kölliker's organ. Simonneau, L., Gallego, M., Pujol, R. J. Comp. Neurol. (2003) [Pubmed]
  19. Expression of P-cadherin distinct from that of E-cadherin in re-epithelialization in neonatal rat skin. Koizumi, M., Matsuzaki, T., Ihara, S. Dev. Growth Differ. (2005) [Pubmed]
  20. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson, K.J., Patel, S.R., Boekelheide, K. Endocrinology (2000) [Pubmed]
  21. Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo. Brady-Kalnay, S.M., Rimm, D.L., Tonks, N.K. J. Cell Biol. (1995) [Pubmed]
  22. Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. Chen, Y.T., Stewart, D.B., Nelson, W.J. J. Cell Biol. (1999) [Pubmed]
  23. mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains. Goldberg, M., Peshkovsky, C., Shifteh, A., Al-Awqati, Q. J. Biol. Chem. (2000) [Pubmed]
  24. Neurabin-II/spinophilin. An actin filament-binding protein with one pdz domain localized at cadherin-based cell-cell adhesion sites. Satoh, A., Nakanishi, H., Obaishi, H., Wada, M., Takahashi, K., Satoh, K., Hirao, K., Nishioka, H., Hata, Y., Mizoguchi, A., Takai, Y. J. Biol. Chem. (1998) [Pubmed]
  25. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. Beall, S.A., Boekelheide, K., Johnson, K.J. J. Androl. (2005) [Pubmed]
  26. Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? Lee, N.P., Mruk, D., Lee, W.M., Cheng, C.Y. Biol. Reprod. (2003) [Pubmed]
  27. Occludin regulates actin cytoskeleton in endothelial cells. Kuwabara, H., Kokai, Y., Kojima, T., Takakuwa, R., Mori, M., Sawada, N. Cell Struct. Funct. (2001) [Pubmed]
  28. Cadherins and cadherin-associated molecules in the developing and maturing rat testis. Byers, S.W., Sujarit, S., Jegou, B., Butz, S., Hoschutzky, H., Herrenknecht, K., MacCalman, C., Blaschuk, O.W. Endocrinology (1994) [Pubmed]
  29. E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Schmidt, C.R., Gi, Y.J., Patel, T.A., Coffey, R.J., Beauchamp, R.D., Pearson, A.S. Surgery (2005) [Pubmed]
  30. Retention of membrane-localized beta-catenin in cells lacking functional polycystin-1 and tuberin. Kugoh, H., Kleymenova, E., Walker, C.L. Mol. Carcinog. (2002) [Pubmed]
  31. Tumor necrosis factor alpha stimulates invasion of Src-activated intestinal cells. Kawai, N., Tsuji, S., Tsujii, M., Ito, T., Yasumaru, M., Kakiuchi, Y., Kimura, A., Komori, M., Sasaki, Y., Hayashi, N., Kawano, S., Dubois, R., Hori, M. Gastroenterology (2002) [Pubmed]
  32. CD2AP contributes to cell migration and adhesion in cultured gastric epithelium. Mustonen, H., Lepistö, A., Lehtonen, S., Lehtonen, E., Puolakkainen, P., Kivilaakso, E. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  33. Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia. Bush, K.T., Tsukamoto, T., Nigam, S.K. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
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