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Ema, H. et al.

"Homing to Niche," a new criterion for hematopoietic stem cells?

By combining cell surface staining with fluorochrome-conjugated monoclonal antibodies and Hoechst 33342 dye supravital staining, Matsuzaki et al. have succeeded in enriching hematopoietic stem cells (HSCs) essentially to homogeneity. When single-cell transplantation analysis was performed using the isolated cells, over 95% of the recipient mice showed long-term multilineage engraftment. The work demonstrates unexpectedly high marrow seeding efficiency of HSCs and proposes high marrow homing capacity as a new criterion for HSCs.[1]

References

"Homing to Niche," a new criterion for hematopoietic stem cells? Ema, H., Nakauchi, H. Immunity (2004) [Pubmed]

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