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MeSH Review

Hematopoietic Stem Cells

 
 
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Disease relevance of Hematopoietic Stem Cells

 

Psychiatry related information on Hematopoietic Stem Cells

 

High impact information on Hematopoietic Stem Cells

  • Stable gene transfer and expression of human ADA has now been obtained in hematopoietic stem cells of mice and, more recently, in large animals [7].
  • (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms [8].
  • To determine whether RNAi suppression of Trp53 could produce a similar phenotype, we introduced several Trp53 short hairpin RNAs (shRNAs) into hematopoietic stem cells derived from E(mu)-Myc transgenic mice, and monitored tumor onset and overall pathology in lethally irradiated recipients [9].
  • Matrix metalloproteinase-9 (MMP-9), induced in BM cells, releases soluble Kit-ligand (sKitL), permitting the transfer of endothelial and hematopoietic stem cells (HSCs) from the quiescent to proliferative niche [10].
  • In an effort to characterize factors that distinguish the definitive adult hematopoietic stem cell (HSC) and primitive progenitors derived from yolk sac or embryonic stem (ES) cells, we examined the effect of ectopic expression of HoxB4, a homeotic selector gene implicated in self-renewal of definitive HSCs [11].
 

Chemical compound and disease context of Hematopoietic Stem Cells

 

Biological context of Hematopoietic Stem Cells

 

Anatomical context of Hematopoietic Stem Cells

 

Associations of Hematopoietic Stem Cells with chemical compounds

 

Gene context of Hematopoietic Stem Cells

 

Analytical, diagnostic and therapeutic context of Hematopoietic Stem Cells

References

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  17. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Wilson, A., Murphy, M.J., Oskarsson, T., Kaloulis, K., Bettess, M.D., Oser, G.M., Pasche, A.C., Knabenhans, C., Macdonald, H.R., Trumpp, A. Genes Dev. (2004) [Pubmed]
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  24. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Brakebusch, C., Fillatreau, S., Potocnik, A.J., Bungartz, G., Wilhelm, P., Svensson, M., Kearney, P., Körner, H., Gray, D., Fässler, R. Immunity (2002) [Pubmed]
  25. Development of hematopoietic stem cell activity in the mouse embryo. Müller, A.M., Medvinsky, A., Strouboulis, J., Grosveld, F., Dzierzak, E. Immunity (1994) [Pubmed]
  26. Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Kumano, K., Chiba, S., Kunisato, A., Sata, M., Saito, T., Nakagami-Yamaguchi, E., Yamaguchi, T., Masuda, S., Shimizu, K., Takahashi, T., Ogawa, S., Hamada, Y., Hirai, H. Immunity (2003) [Pubmed]
  27. Surface molecules of hematopoietic stem cells: requirement for sialic acid in spleen colony formation. Tonelli, Q., Meintz, R.H. Science (1977) [Pubmed]
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  30. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. Hattori, K., Dias, S., Heissig, B., Hackett, N.R., Lyden, D., Tateno, M., Hicklin, D.J., Zhu, Z., Witte, L., Crystal, R.G., Moore, M.A., Rafii, S. J. Exp. Med. (2001) [Pubmed]
  31. Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. Qin, G., Ii, M., Silver, M., Wecker, A., Bord, E., Ma, H., Gavin, M., Goukassian, D.A., Yoon, Y.S., Papayannopoulou, T., Asahara, T., Kearney, M., Thorne, T., Curry, C., Eaton, L., Heyd, L., Dinesh, D., Kishore, R., Zhu, Y., Losordo, D.W. J. Exp. Med. (2006) [Pubmed]
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  33. Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Amsellem, S., Pflumio, F., Bardinet, D., Izac, B., Charneau, P., Romeo, P.H., Dubart-Kupperschmitt, A., Fichelson, S. Nat. Med. (2003) [Pubmed]
  34. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Hock, H., Meade, E., Medeiros, S., Schindler, J.W., Valk, P.J., Fujiwara, Y., Orkin, S.H. Genes Dev. (2004) [Pubmed]
  35. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. North, T.E., de Bruijn, M.F., Stacy, T., Talebian, L., Lind, E., Robin, C., Binder, M., Dzierzak, E., Speck, N.A. Immunity (2002) [Pubmed]
  36. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Adolfsson, J., Borge, O.J., Bryder, D., Theilgaard-Mönch, K., Astrand-Grundström, I., Sitnicka, E., Sasaki, Y., Jacobsen, S.E. Immunity (2001) [Pubmed]
  37. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Miyoshi, H., Smith, K.A., Mosier, D.E., Verma, I.M., Torbett, B.E. Science (1999) [Pubmed]
  38. Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5. Kyba, M., Perlingeiro, R.C., Hoover, R.R., Lu, C.W., Pierce, J., Daley, G.Q. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  39. Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Zhang, C.C., Steele, A.D., Lindquist, S., Lodish, H.F. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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