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MeSH Review

Hematopoietic Stem Cells

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Disease relevance of Hematopoietic Stem Cells


Psychiatry related information on Hematopoietic Stem Cells


High impact information on Hematopoietic Stem Cells

  • Stable gene transfer and expression of human ADA has now been obtained in hematopoietic stem cells of mice and, more recently, in large animals [7].
  • (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms [8].
  • To determine whether RNAi suppression of Trp53 could produce a similar phenotype, we introduced several Trp53 short hairpin RNAs (shRNAs) into hematopoietic stem cells derived from E(mu)-Myc transgenic mice, and monitored tumor onset and overall pathology in lethally irradiated recipients [9].
  • Matrix metalloproteinase-9 (MMP-9), induced in BM cells, releases soluble Kit-ligand (sKitL), permitting the transfer of endothelial and hematopoietic stem cells (HSCs) from the quiescent to proliferative niche [10].
  • In an effort to characterize factors that distinguish the definitive adult hematopoietic stem cell (HSC) and primitive progenitors derived from yolk sac or embryonic stem (ES) cells, we examined the effect of ectopic expression of HoxB4, a homeotic selector gene implicated in self-renewal of definitive HSCs [11].

Chemical compound and disease context of Hematopoietic Stem Cells


Biological context of Hematopoietic Stem Cells


Anatomical context of Hematopoietic Stem Cells


Associations of Hematopoietic Stem Cells with chemical compounds


Gene context of Hematopoietic Stem Cells


Analytical, diagnostic and therapeutic context of Hematopoietic Stem Cells


  1. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Bunting, K.D., Sangster, M.Y., Ihle, J.N., Sorrentino, B.P. Nat. Med. (1998) [Pubmed]
  2. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. Bacchetta, R., Bigler, M., Touraine, J.L., Parkman, R., Tovo, P.A., Abrams, J., de Waal Malefyt, R., de Vries, J.E., Roncarolo, M.G. J. Exp. Med. (1994) [Pubmed]
  3. Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. Muraro, P.A., Douek, D.C., Packer, A., Chung, K., Guenaga, F.J., Cassiani-Ingoni, R., Campbell, C., Memon, S., Nagle, J.W., Hakim, F.T., Gress, R.E., McFarland, H.F., Burt, R.K., Martin, R. J. Exp. Med. (2005) [Pubmed]
  4. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. Dias, S., Hattori, K., Zhu, Z., Heissig, B., Choy, M., Lane, W., Wu, Y., Chadburn, A., Hyjek, E., Gill, M., Hicklin, D.J., Witte, L., Moore, M.A., Rafii, S. J. Clin. Invest. (2000) [Pubmed]
  5. Amphotericin B potentiation of the cytotoxicity of anticancer agents against both normal hematopoietic and leukemia cells in mice. Valeriote, F., Medoff, G., Tolen, S., Dieckman, J. J. Natl. Cancer Inst. (1984) [Pubmed]
  6. Once-daily intravenous busulfan and fludarabine: clinical and pharmacokinetic results of a myeloablative, reduced-toxicity conditioning regimen for allogeneic stem cell transplantation in AML and MDS. de Lima, M., Couriel, D., Thall, P.F., Wang, X., Madden, T., Jones, R., Shpall, E.J., Shahjahan, M., Pierre, B., Giralt, S., Korbling, M., Russell, J.A., Champlin, R.E., Andersson, B.S. Blood (2004) [Pubmed]
  7. Gene therapy of the immune system. Cournoyer, D., Caskey, C.T. Annu. Rev. Immunol. (1993) [Pubmed]
  8. Pten, tumorigenesis, and stem cell self-renewal. Rossi, D.J., Weissman, I.L. Cell (2006) [Pubmed]
  9. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Hemann, M.T., Fridman, J.S., Zilfou, J.T., Hernando, E., Paddison, P.J., Cordon-Cardo, C., Hannon, G.J., Lowe, S.W. Nat. Genet. (2003) [Pubmed]
  10. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Heissig, B., Hattori, K., Dias, S., Friedrich, M., Ferris, B., Hackett, N.R., Crystal, R.G., Besmer, P., Lyden, D., Moore, M.A., Werb, Z., Rafii, S. Cell (2002) [Pubmed]
  11. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Kyba, M., Perlingeiro, R.C., Daley, G.Q. Cell (2002) [Pubmed]
  12. Development of HIV vectors for anti-HIV gene therapy. Poeschla, E., Corbeau, P., Wong-Staal, F. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. Chemical suppression of a subpopulation of primitive hematopoietic progenitor cells: 1,3-butadiene produces a hematopoietic defect similar to steel or white spotted mutations in mice. Colagiovanni, D.B., Stillman, W.S., Irons, R.D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  14. Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. Shiotsu, Y., Neckers, L.M., Wortman, I., An, W.G., Schulte, T.W., Soga, S., Murakata, C., Tamaoki, T., Akinaga, S. Blood (2000) [Pubmed]
  15. Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells. Bornhauser, M., Storer, B., Slattery, J.T., Appelbaum, F.R., Deeg, H.J., Hansen, J., Martin, P.J., McDonald, G.B., Nichols, W.G., Radich, J., Woolfrey, A., Jenke, A., Schleyer, E., Thiede, C., Ehninger, G., Anasetti, C. Blood (2003) [Pubmed]
  16. Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Tiberghien, P., Ferrand, C., Lioure, B., Milpied, N., Angonin, R., Deconinck, E., Certoux, J.M., Robinet, E., Saas, P., Petracca, B., Juttner, C., Reynolds, C.W., Longo, D.L., Hervé, P., Cahn, J.Y. Blood (2001) [Pubmed]
  17. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Wilson, A., Murphy, M.J., Oskarsson, T., Kaloulis, K., Bettess, M.D., Oser, G.M., Pasche, A.C., Knabenhans, C., Macdonald, H.R., Trumpp, A. Genes Dev. (2004) [Pubmed]
  18. Notch and the immune system. Maillard, I., Adler, S.H., Pear, W.S. Immunity (2003) [Pubmed]
  19. Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit. Lambert, J.F., Liu, M., Colvin, G.A., Dooner, M., McAuliffe, C.I., Becker, P.S., Forget, B.G., Weissman, S.M., Quesenberry, P.J. J. Exp. Med. (2003) [Pubmed]
  20. Telomerase activation and rejuvenation of telomere length in stimulated T cells derived from serially transplanted hematopoietic stem cells. Allsopp, R.C., Cheshier, S., Weissman, I.L. J. Exp. Med. (2002) [Pubmed]
  21. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. Rufer, N., Brümmendorf, T.H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., Lansdorp, P.M. J. Exp. Med. (1999) [Pubmed]
  22. A lymphoproliferative abnormality associated with inappropriate expression of the Thy-1 antigen in transgenic mice. Chen, S., Botteri, F., van der Putten, H., Landel, C.P., Evans, G.A. Cell (1987) [Pubmed]
  23. Binding of L-selectin to the vascular sialomucin CD34. Baumheter, S., Singer, M.S., Henzel, W., Hemmerich, S., Renz, M., Rosen, S.D., Lasky, L.A. Science (1993) [Pubmed]
  24. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Brakebusch, C., Fillatreau, S., Potocnik, A.J., Bungartz, G., Wilhelm, P., Svensson, M., Kearney, P., Körner, H., Gray, D., Fässler, R. Immunity (2002) [Pubmed]
  25. Development of hematopoietic stem cell activity in the mouse embryo. Müller, A.M., Medvinsky, A., Strouboulis, J., Grosveld, F., Dzierzak, E. Immunity (1994) [Pubmed]
  26. Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Kumano, K., Chiba, S., Kunisato, A., Sata, M., Saito, T., Nakagami-Yamaguchi, E., Yamaguchi, T., Masuda, S., Shimizu, K., Takahashi, T., Ogawa, S., Hamada, Y., Hirai, H. Immunity (2003) [Pubmed]
  27. Surface molecules of hematopoietic stem cells: requirement for sialic acid in spleen colony formation. Tonelli, Q., Meintz, R.H. Science (1977) [Pubmed]
  28. "Homing to Niche," a new criterion for hematopoietic stem cells? Ema, H., Nakauchi, H. Immunity (2004) [Pubmed]
  29. Studies of hematopoietic stem cells spared by 5-fluorouracil. Van Zant, G. J. Exp. Med. (1984) [Pubmed]
  30. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. Hattori, K., Dias, S., Heissig, B., Hackett, N.R., Lyden, D., Tateno, M., Hicklin, D.J., Zhu, Z., Witte, L., Crystal, R.G., Moore, M.A., Rafii, S. J. Exp. Med. (2001) [Pubmed]
  31. Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. Qin, G., Ii, M., Silver, M., Wecker, A., Bord, E., Ma, H., Gavin, M., Goukassian, D.A., Yoon, Y.S., Papayannopoulou, T., Asahara, T., Kearney, M., Thorne, T., Curry, C., Eaton, L., Heyd, L., Dinesh, D., Kishore, R., Zhu, Y., Losordo, D.W. J. Exp. Med. (2006) [Pubmed]
  32. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. Sasazuki, T., Juji, T., Morishima, Y., Kinukawa, N., Kashiwabara, H., Inoko, H., Yoshida, T., Kimura, A., Akaza, T., Kamikawaji, N., Kodera, Y., Takaku, F. N. Engl. J. Med. (1998) [Pubmed]
  33. Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Amsellem, S., Pflumio, F., Bardinet, D., Izac, B., Charneau, P., Romeo, P.H., Dubart-Kupperschmitt, A., Fichelson, S. Nat. Med. (2003) [Pubmed]
  34. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Hock, H., Meade, E., Medeiros, S., Schindler, J.W., Valk, P.J., Fujiwara, Y., Orkin, S.H. Genes Dev. (2004) [Pubmed]
  35. Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. North, T.E., de Bruijn, M.F., Stacy, T., Talebian, L., Lind, E., Robin, C., Binder, M., Dzierzak, E., Speck, N.A. Immunity (2002) [Pubmed]
  36. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Adolfsson, J., Borge, O.J., Bryder, D., Theilgaard-Mönch, K., Astrand-Grundström, I., Sitnicka, E., Sasaki, Y., Jacobsen, S.E. Immunity (2001) [Pubmed]
  37. Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors. Miyoshi, H., Smith, K.A., Mosier, D.E., Verma, I.M., Torbett, B.E. Science (1999) [Pubmed]
  38. Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5. Kyba, M., Perlingeiro, R.C., Hoover, R.R., Lu, C.W., Pierce, J., Daley, G.Q. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  39. Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Zhang, C.C., Steele, A.D., Lindquist, S., Lodish, H.F. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  40. Identification and characterization of hematopoietic stem cells from the yolk sac of the early mouse embryo. Huang, H., Auerbach, R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  41. Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy. Giralt, S., Estey, E., Albitar, M., van Besien, K., Rondón, G., Anderlini, P., O'Brien, S., Khouri, I., Gajewski, J., Mehra, R., Claxton, D., Andersson, B., Beran, M., Przepiorka, D., Koller, C., Kornblau, S., Kørbling, M., Keating, M., Kantarjian, H., Champlin, R. Blood (1997) [Pubmed]
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