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Liu, Z. et al.

Liu, Stevenson, Barrett, Kastis, Bettan, Furenlid, Wilson, Woolfenden,

Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system.

Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/ D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/ D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/ D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.[1]

References

Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system. Liu, Z., Stevenson, G.D., Barrett, H.H., Kastis, G.A., Bettan, M., Furenlid, L.R., Wilson, D.W., Woolfenden, J.M. Nucl. Med. Biol. (2004) [Pubmed]

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