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Chemical Compound Review

Myoview     2-[bis(2-ethoxyethyl) phosphanyl]ethyl...

Synonyms: Tetrofosmin, AG-J-99163, CHEMBL1615784, ACMC-20d777, AC1L1HSP, ...
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Disease relevance of Tetrofosmin


High impact information on Tetrofosmin


Chemical compound and disease context of Tetrofosmin


Biological context of Tetrofosmin

  • RESULTS: Thallium was most sensitive in predicting hibernation (88%) and MRI most specific (84%); and, although there was good agreement between thallium and tetrofosmin (85%), agreement between MRI and thallium (59%) or tetrofosmin (59%) was poor [13].
  • The kinetics and cellular uptake of 99mTc-2-hexakis 2-methoxyiso-butyl-isonitrile (MIBI) and 99mTc-1 ,2-bis[bis(2-ethoxyethyl)phosphino]ethane (tetrofosmin) into malignant versus nonmalignant human breast cell lines were investigated and compared [14].
  • Each pig received a simultaneous injection of sestamibi and either tetrofosmin (group 1, n = 5) or Q12 (group 2, n = 4) labeled with either 99mTc or 95mTc (physical half-life, 61 d; photon energy, 204 keV) during pharmacologic vasodilation [15].
  • CONCLUSIONS: Stress tetrofosmin perfusion tomography is a valuable method to detect coronary artery disease and to assess tissue viability with accuracy similar to that of stress 201Tl tomography [16].
  • Assessment of left ventricular ejection fraction by four different methods using 99mTc tetrofosmin gated SPECT in patients with small hearts: correlation with gated blood pool [17].

Anatomical context of Tetrofosmin


Associations of Tetrofosmin with other chemical compounds


Gene context of Tetrofosmin


Analytical, diagnostic and therapeutic context of Tetrofosmin


  1. Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain. Kawai, Y., Tsukamoto, E., Nozaki, Y., Morita, K., Sakurai, M., Tamaki, N. J. Am. Coll. Cardiol. (2001) [Pubmed]
  2. Quantitative rest technetium-99m tetrofosmin imaging in predicting functional recovery after revascularization: comparison with rest-redistribution thallium-201. Matsunari, I., Fujino, S., Taki, J., Senma, J., Aoyama, T., Wakasugi, T., Hirai, J., Saga, T., Yamamoto, S., Tonami, N. J. Am. Coll. Cardiol. (1997) [Pubmed]
  3. Clinical value of acute rest technetium-99m tetrofosmin tomographic myocardial perfusion imaging in patients with acute chest pain and nondiagnostic electrocardiograms. Heller, G.V., Stowers, S.A., Hendel, R.C., Herman, S.D., Daher, E., Ahlberg, A.W., Baron, J.M., Mendes de Leon, C.F., Rizzo, J.A., Wackers, F.J. J. Am. Coll. Cardiol. (1998) [Pubmed]
  4. Comparison of 201Tl, 99mTc-tetrofosmin, and dobutamine magnetic resonance imaging for identifying hibernating myocardium. Gunning, M.G., Anagnostopoulos, C., Knight, C.J., Pepper, J., Burman, E.D., Davies, G., Fox, K.M., Pennell, D.J., Ell, P.J., Underwood, S.R. Circulation (1998) [Pubmed]
  5. Myocardial uptake of 99mTc-tetrofosmin, sestamibi, and 201Tl in a model of acute coronary reperfusion. Takahashi, N., Reinhardt, C.P., Marcel, R., Leppo, J.A. Circulation (1996) [Pubmed]
  6. Ethnic differences in the prognostic value of stress technetium-99m tetrofosmin gated single-photon emission computed tomography myocardial perfusion imaging. Shaw, L.J., Hendel, R.C., Cerquiera, M., Mieres, J.H., Alazraki, N., Krawczynska, E., Borges-Neto, S., Maddahi, J., Bairey Merz, C.N. J. Am. Coll. Cardiol. (2005) [Pubmed]
  7. Assessment of clinical features in transient left ventricular apical ballooning. Abe, Y., Kondo, M., Matsuoka, R., Araki, M., Dohyama, K., Tanio, H. J. Am. Coll. Cardiol. (2003) [Pubmed]
  8. Right ventricular abnormalities assessed by myocardial single-photon emission computed tomography using technetium-99m sestamibi/tetrofosmin in right ventricle-originated ventricular tachyarrhythmias. Eguchi, M., Tsuchihashi, K., Nakata, T., Hashimoto, A., Shimamoto, K. J. Am. Coll. Cardiol. (2000) [Pubmed]
  9. Technetium-99m-tetrofosmin myocardial imaging: a comparison with thallium-201 and angiography. Rigo, P., Leclercq, B., Itti, R., Lahiri, A., Braat, S. J. Nucl. Med. (1994) [Pubmed]
  10. Using technetium 99m tetrofosmin parathyroid imaging to detect parathyroid adenoma and its relation to P-glycoprotein expression. Wu, H.S., Liu, Y.C., Kao, A., Wang, J.J., Ho, S.T. Surgery (2002) [Pubmed]
  11. Accuracy of dobutamine tetrofosmin myocardial perfusion imaging for the noninvasive diagnosis of transplant coronary artery stenosis. Elhendy, A., Sozzi, F.B., van Domburg, R.T., Vantrimpont, P., Valkema, R., Krenning, E.P., Roelandt, J.R., Maat, L.P., Balk, A.H. J. Heart Lung Transplant. (2000) [Pubmed]
  12. The usefulness of adenosine 99mTc tetrofosmin SPECT for the diagnosis of left anterior descending coronary artery disease in patients with chest pain and left bundle branch block. Feola, M., Biggi, A., Vado, A., Ribichini, F., Ferrero, V., Leonardi, G., Uslenghi, E. Nuclear medicine communications. (2004) [Pubmed]
  13. The histology of viable and hibernating myocardium in relation to imaging characteristics. Gunning, M.G., Kaprielian, R.R., Pepper, J., Pennell, D.J., Sheppard, M.N., Severs, N.J., Fox, K.M., Underwood, S.R. J. Am. Coll. Cardiol. (2002) [Pubmed]
  14. Uptake of 99mTc-MIBI and 99mTc-tetrofosmin into malignant versus nonmalignant breast cell lines. Rodrigues, M., Chehne, F., Kalinowska, W., Berghammer, P., Zielinski, C., Sinzinger, H. J. Nucl. Med. (2000) [Pubmed]
  15. Comparison of sestamibi, tetrofosmin, and Q12 retention in porcine myocardium. Matsunari, I., Haas, F., Nguyen, N.T., Reidel, G., Wolf, I., Senekowitsch-Schmidtke, R., Stöcklin, G., Schwaiger, M. J. Nucl. Med. (2001) [Pubmed]
  16. Myocardial tomography using technetium-99m-tetrofosmin to evaluate coronary artery disease. Tamaki, N., Takahashi, N., Kawamoto, M., Torizuka, T., Tadamura, E., Yonekura, Y., Okuda, K., Nohara, R., Sasayama, S., Konishi, J. J. Nucl. Med. (1994) [Pubmed]
  17. Assessment of left ventricular ejection fraction by four different methods using 99mTc tetrofosmin gated SPECT in patients with small hearts: correlation with gated blood pool. Khalil, M.M., Elgazzar, A., Khalil, W., Omar, A., Ziada, G. Nuclear medicine communications. (2005) [Pubmed]
  18. Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Zaret, B.L., Rigo, P., Wackers, F.J., Hendel, R.C., Braat, S.H., Iskandrian, A.S., Sridhara, B.S., Jain, D., Itti, R., Serafini, A.N. Circulation (1995) [Pubmed]
  19. Technetium-99m-tetrofosmin for parathyroid scintigraphy: a comparison with sestamibi. Fjeld, J.G., Erichsen, K., Pfeffer, P.F., Clausen, O.P., Rootwelt, K. J. Nucl. Med. (1997) [Pubmed]
  20. Localization of parathyroid glands using technetium-99m-tetrofosmin imaging. Ishibashi, M., Nishida, H., Strauss, H.W., Kojima, K., Fujito, H., Watanabe, J., Hiromatsu, Y., Hayabuchi, N. J. Nucl. Med. (1997) [Pubmed]
  21. Myocardial perfusion after angioplasty in patients suspected of having single-vessel coronary artery disease: improvement detected at rest-stress first-pass perfusion MR imaging--initial experience. Fenchel, M., Franow, A., Stauder, N.I., Kramer, U., Helber, U., Claussen, C.D., Miller, S. Radiology. (2005) [Pubmed]
  22. Assessing coronary artery disease with dipyridamole technetium-99m-tetrofosmin SPECT: a multicenter trial. He, Z.X., Iskandrian, A.S., Gupta, N.C., Verani, M.S. J. Nucl. Med. (1997) [Pubmed]
  23. Nitrate administration to enhance the detection of myocardial viability by technetium-99m tetrofosmin single-photon emission tomography. Flotats, A., Carrió, I., Estorch, M., Bernà, L., Catafau, A.M., Marí, C., Ballester, M. European journal of nuclear medicine. (1997) [Pubmed]
  24. Technetium 99m-labeled tetrofosmin and iodine 123-labeled metaiodobenzylguanidine scintigraphy in the assessment of transmyocardial laser revascularization. Muxí, A., Magriñá, J., Martín, F., Josa, M., Fuster, D., Setoain, F.J., Pérez-Villa, F., Pavía, J., Bosch, X. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  25. Monitoring interactions at ATP-dependent drug efflux pumps. Hendrikse, N.H. Curr. Pharm. Des. (2000) [Pubmed]
  26. To predict response chemotherapy using technetium-99m tetrofosmin chest images in patients with untreated small cell lung cancer and compare with p-glycoprotein, multidrug resistance related protein-1, and lung resistance-related protein expression. Kuo, T.H., Liu, F.Y., Chuang, C.Y., Wu, H.S., Wang, J.J., Kao, A. Nucl. Med. Biol. (2003) [Pubmed]
  27. Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin. Liu, Z., Stevenson, G.D., Barrett, H.H., Furenlid, L.R., Wilson, D.W., Kastis, G.A., Bettan, M., Woolfenden, J.M. Nucl. Med. Biol. (2005) [Pubmed]
  28. 99mTc tetrofosmin scintigraphy in acute leukaemia: the relationship between marrow uptake of tetrofosmin and P-glycoprotein and chemotherapy response. Sükan, A., Yapar, Z., SAhin, B., Kara, O., Fuat Yapar, A., CEtiner, S., Kibar, M. Nuclear medicine communications. (2004) [Pubmed]
  29. Comparison of the expression of P-glycoprotein, Ki-67, and P-53 to technetium-99m tetrofosmin mammoscintigraphic findings. Liu, T.J., Tsai, S.C., Ho, Y.J., Sun, S.S., Kao, C.H. Cancer Invest. (2002) [Pubmed]
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