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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Class 1 integrons increase trimethoprim-sulfamethoxazole MICs against epidemiologically unrelated Stenotrophomonas maltophilia isolates.

Twenty-five plasmid-specified antimicrobial resistance determinants common to gram-negative bacilli from nosocomial infection were investigated from 31 Stenotrophomonas maltophilia isolates. Twenty-four clones were identified by pulsed-field gel electrophoresis, and in three clones that exhibited an increased trimethoprim-sulfamethoxazole MIC, the sul1 determinant was found. These results support not only the higher spread of class 1 integrons compared to other mechanisms but also the potential limitation of using trimethoprim-sulfamethoxazole for therapy of severe S. maltophilia infections.[1]

References

  1. Class 1 integrons increase trimethoprim-sulfamethoxazole MICs against epidemiologically unrelated Stenotrophomonas maltophilia isolates. Barbolla, R., Catalano, M., Orman, B.E., Famiglietti, A., Vay, C., Smayevsky, J., Centrón, D., Piñeiro, S.A. Antimicrob. Agents Chemother. (2004) [Pubmed]
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