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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The TraM protein of the conjugative plasmid F binds to the origin of transfer of the F and ColE1 plasmids.

The gene encoding the TraM protein of the conjugative plasmid F was cloned, overexpressed and the gene product was purified. The TraM protein was found in the cytoplasm of cells carrying the F plasmid with a smaller amount in the inner membrane. DNase I footprinting experiments showed that the purified protein protects three regions in the F oriT locus with different affinity for the upper and lower strands of DNA. A 15-nucleotide motif was identified within the protected regions that represented the DNA-binding site. The TraM protein was also found to bind to a sequence in the oriT region of the non-conjugative plasmid ColE1 that resembles the three binding sites in the F oriT region.[1]

References

  1. The TraM protein of the conjugative plasmid F binds to the origin of transfer of the F and ColE1 plasmids. Di Laurenzio, L., Frost, L.S., Paranchych, W. Mol. Microbiol. (1992) [Pubmed]
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