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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Post-irradiation protective effect of irsogladine maleate on intestinal crypt stem cells in mice.

Radioprotective effect of irsogladine maleate, an anti-ulcer drug, on the intestinal crypt stem cell survival was studied in mice using a crypt microcolony assay. Irsogladine maleate was injected intraperitoneally immediately after irradiation and then, daily for three days. A successive administration of the drug following 10 Gy of irradiation increased the survival of intestinal stem cells with a clear dose-related trend. In order to estimate the D0, survival curves were determined for X-ray plus placebo and X-ray plus 10 mg/kg of irsogladine maleate. The D0, for X-ray plus the drug was 2.2 Gy while it was 1.9 Gy for X-ray plus placebo. These findings suggest that isogladine maleate can be applied for the alleviation of intestinal damages in heavily irradiated people by radiation accidents.[1]

References

  1. Post-irradiation protective effect of irsogladine maleate on intestinal crypt stem cells in mice. Kurishita, A., Takai, Y., Ueda, F., Sakamoto, K., Ono, T. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1992) [Pubmed]
 
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