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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use.

In 12 healthy volunteers, paracetamol pharmacokinetics were compared following administration of 1 g propacetamol HCl given intravenously over a 15-min period and 500 mg paracetamol given orally. Mean +/- SD total AUC (microgram/ml.h) following the iv formulation was significantly (P < 0.01) greater than following oral paracetamol (25.53 +/- 4.27 vs 21.04 +/- 4.49) corresponding to a mean oral bioavailability of paracetamol of 82.2 +/- 9.4%. Between 1 and 2 h after administration, paracetamol plasma concentrations became very similar following both formulations. In another study, 2 g propacetamol HCl was given both as a 15-min infusion and as a 2-min bolus injection to six healthy volunteers. Contrary to mild to moderate local discomfort experienced during the 2-min bolus injection, the 15-min infusion was well tolerated without any complaints reported.[1]

References

  1. Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use. Depré, M., van Hecken, A., Verbesselt, R., Tjandra-Maga, T.B., Gerin, M., de Schepper, P.J. Fundamental & clinical pharmacology. (1992) [Pubmed]
 
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