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Chemical Compound Review

Acephen     N-(4-hydroxyphenyl)ethanamide

Synonyms: Acetaco, Panadol, Tylenol, Acamol, Algotropyl, ...
 
 
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Disease relevance of Tylenol

 

Psychiatry related information on Tylenol

 

High impact information on Tylenol

 

Chemical compound and disease context of Tylenol

 

Biological context of Tylenol

 

Anatomical context of Tylenol

 

Associations of Tylenol with other chemical compounds

 

Gene context of Tylenol

  • One potential target of JNK is Bax translocation, which was enhanced by APAP and blocked by the JNK inhibitor [31].
  • COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression [32].
  • Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs [33].
  • CYP1A2 substrates include aflatoxin B1, acetaminophen, and a variety of environmental arylamines [34].
  • Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase [35].
  • We have identified a 2-signal requirement (Tlr9 and the Nalp3 inflammasome) for acetaminophen-induced hepatotoxicity and some potential therapeutic approaches [36].
 

Analytical, diagnostic and therapeutic context of Tylenol

References

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  21. Potentiation of acetaminophen hepatotoxicity by alcohol. McClain, C.J., Kromhout, J.P., Peterson, F.J., Holtzman, J.L. JAMA (1980) [Pubmed]
  22. Acetaminophen overdose in the third trimester of pregnancy. Byer, A.J., Traylor, T.R., Semmer, J.R. JAMA (1982) [Pubmed]
  23. Protective effect of acetaminophen against aspirin- and ethanol-induced damage to the human gastric mucosa. Stern, A.I., Hogan, D.L., Kahn, L.H., Isenberg, J.I. Gastroenterology (1984) [Pubmed]
  24. Infection and the progression of hepatic encephalopathy in acute liver failure. Vaquero, J., Polson, J., Chung, C., Helenowski, I., Schiodt, F.V., Reisch, J., Lee, W.M., Blei, A.T. Gastroenterology (2003) [Pubmed]
  25. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Liu, Z.X., Govindarajan, S., Kaplowitz, N. Gastroenterology (2004) [Pubmed]
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  29. Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. Loebl, D.H., Craig, R.M., Culic, D.D., Ridolfo, A.S., Falk, J., Schmid, F.R. JAMA (1977) [Pubmed]
  30. Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults. Gelotte, C.K., Auiler, J.F., Lynch, J.M., Temple, A.R., Slattery, J.T. Clin. Pharmacol. Ther. (2007) [Pubmed]
  31. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gunawan, B.K., Liu, Z.X., Han, D., Hanawa, N., Gaarde, W.A., Kaplowitz, N. Gastroenterology (2006) [Pubmed]
  32. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Chandrasekharan, N.V., Dai, H., Roos, K.L., Evanson, N.K., Tomsik, J., Elton, T.S., Simmons, D.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  33. Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs. Simmons, D.L., Botting, R.M., Robertson, P.M., Madsen, M.L., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  34. Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. Liang, H.C., Li, H., McKinnon, R.A., Duffy, J.J., Potter, S.S., Puga, A., Nebert, D.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  35. Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Bourdi, M., Masubuchi, Y., Reilly, T.P., Amouzadeh, H.R., Martin, J.L., George, J.W., Shah, A.G., Pohl, L.R. Hepatology (2002) [Pubmed]
  36. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. Imaeda, A.B., Watanabe, A., Sohail, M.A., Mahmood, S., Mohamadnejad, M., Sutterwala, F.S., Flavell, R.A., Mehal, W.Z. J. Clin. Invest. (2009) [Pubmed]
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  40. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Davern, T.J., James, L.P., Hinson, J.A., Polson, J., Larson, A.M., Fontana, R.J., Lalani, E., Munoz, S., Shakil, A.O., Lee, W.M. Gastroenterology (2006) [Pubmed]
 
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