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Chemical Compound Review

Propacetamol     (4-acetamidophenyl) 2-diethylaminoethanoate

Synonyms: Propacetamolum, Pro-Dafalgan, SureCN26155, CHEMBL1851805, AC1L2ALY, ...
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Disease relevance of Propacetamol


High impact information on Propacetamol


Chemical compound and disease context of Propacetamol


Biological context of Propacetamol


Anatomical context of Propacetamol


Associations of Propacetamol with other chemical compounds


Gene context of Propacetamol

  • The cumulative dose of morphine at 72 h was smaller in the Propacetamol group than in the Placebo group (60.3 +/- 20.5 vs 112.2 +/- 39.1 mg; P < 0.001) [14].
  • Since paracetamol provides a good substrate to study UGT (1A6) activity, urinary metabolites of propacetamol were determined in neonates in whom propacetamol was repeatedly administered [27].

Analytical, diagnostic and therapeutic context of Propacetamol


  1. Homozygous G6PD deficiency and propacetamol induced hemolysis. Oliver, M., Coton, T., Badens, C., Dehan, C., Lena-Russo, D., Moalic, J.L. Haematologica (2001) [Pubmed]
  2. The morphine-sparing effect of propacetamol in orthopedic postoperative pain. Delbos, A., Boccard, E. Journal of pain and symptom management. (1995) [Pubmed]
  3. A randomized, double-blind comparison between parecoxib sodium and propacetamol for parenteral postoperative analgesia after inguinal hernia repair in adult patients. Beaussier, M., Weickmans, H., Paugam, C., Lavazais, S., Baechle, J.P., Goater, P., Buffin, A., Loriferne, J.F., Perier, J.F., Didelot, J.P., Mosbah, A., Said, R., Lienhart, A. Anesth. Analg. (2005) [Pubmed]
  4. Airborne contact dermatitis from propacetamol. Mathelier-Fusade, P., Mansouri, S., Aïssaoui, M., Chabane, M.H., Aractingi, S., Leynadier, F. Contact Derm. (1997) [Pubmed]
  5. Operative stress response is reduced after laparoscopic compared to open cholecystectomy: the relationship with postoperative pain and ileus. Le Blanc-Louvry, I., Coquerel, A., Koning, E., Maillot, C., Ducrotté, P. Dig. Dis. Sci. (2000) [Pubmed]
  6. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Sinatra, R.S., Jahr, J.S., Reynolds, L.W., Viscusi, E.R., Groudine, S.B., Payen-Champenois, C. Anesthesiology (2005) [Pubmed]
  7. Antipyretic efficacy and tolerability of a single intravenous dose of the acetaminophen prodrug propacetamol in children: a randomized, double-blind, placebo-controlled trial. Walson, P.D., Jones, J., Chesney, R., Rodarte, A. Clinical therapeutics. (2006) [Pubmed]
  8. Intravenous acetaminophen (paracetamol): comparable analgesic efficacy, but better local safety than its prodrug, propacetamol, for postoperative pain after third molar surgery. Moller, P.L., Juhl, G.I., Payen-Champenois, C., Skoglund, L.A. Anesth. Analg. (2005) [Pubmed]
  9. Assessing analgesia in single and repeated administrations of propacetamol for postoperative pain: comparison with morphine after dental surgery. Van Aken, H., Thys, L., Veekman, L., Buerkle, H. Anesth. Analg. (2004) [Pubmed]
  10. Diclofenac and/or propacetamol for postoperative pain management after cesarean delivery in patients receiving patient controlled analgesia morphine. Siddik, S.M., Aouad, M.T., Jalbout, M.I., Rizk, L.B., Kamar, G.H., Baraka, A.S. Regional anesthesia and pain medicine. (2001) [Pubmed]
  11. Mechanism of allergic contact dermatitis from propacetamol: sensitization to activated N,N-diethylglycine. Berl, V., Barbaud, A., Lepoittevin, J.P. Contact Derm. (1998) [Pubmed]
  12. Outpatient laparoscopic splenectomy: patient safety and satisfaction. Edwin, B., Skattum, X., Rãder, J., Trondsen, E., Buanes, T. Surgical endoscopy. (2004) [Pubmed]
  13. Occupational contact dermatitis to propacetamol. Allergological and chemical investigations in two new cases. Barbaud, A., Reichert-Penetrat, S., Tréchot, P., Cuny, J.F., Weber, M., Schmutz, J.L. Dermatology (Basel) (1997) [Pubmed]
  14. Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Hernández-Palazón, J., Tortosa, J.A., Martínez-Lage, J.F., Pérez-Flores, D. Anesth. Analg. (2001) [Pubmed]
  15. Propacetamol as adjunctive treatment for postoperative pain after cardiac surgery. Lahtinen, P., Kokki, H., Hendolin, H., Hakala, T., Hynynen, M. Anesth. Analg. (2002) [Pubmed]
  16. Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use. Depré, M., van Hecken, A., Verbesselt, R., Tjandra-Maga, T.B., Gerin, M., de Schepper, P.J. Fundamental & clinical pharmacology. (1992) [Pubmed]
  17. Early bioavailability of paracetamol after oral or intravenous administration. Holmér Pettersson, P., Owall, A., Jakobsson, J. Acta anaesthesiologica Scandinavica. (2004) [Pubmed]
  18. Platelet dysfunction after intravenous ketorolac or propacetamol. Niemi, T.T., Backman, J.T., Syrjälä, M.T., Viinikka, L.U., Rosenberg, P.H. Acta anaesthesiologica Scandinavica. (2000) [Pubmed]
  19. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Bannwarth, B., Netter, P., Lapicque, F., Gillet, P., Péré, P., Boccard, E., Royer, R.J., Gaucher, A. British journal of clinical pharmacology. (1992) [Pubmed]
  20. The effect of a single intravenous dose of metamizol 2 g, ketorolac 30 mg and propacetamol 1 g on haemodynamic parameters and postoperative pain after heart surgery. Avellaneda, C., Gómez, A., Martos, F., Rubio, M., Sarmiento, J., de la Cuesta, F.S. European journal of anaesthesiology. (2000) [Pubmed]
  21. Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats. Galunska, B., Marazova, K., Tankova, T., Popov, A., Frangov, P., Krushkov, I., Di Massa, A. Pharmacol. Res. (2002) [Pubmed]
  22. Propacetamol and ketoprofen after thyroidectomy. Fourcade, O., Sanchez, P., Kern, D., Mazoit, J.X., Minville, V., Samii, K. European journal of anaesthesiology. (2005) [Pubmed]
  23. Symptomatic intravenous antipyretic therapy: efficacy of metamizol, diclofenac, and propacetamol. Oborilová, A., Mayer, J., Pospísil, Z., Korístek, Z. Journal of pain and symptom management. (2002) [Pubmed]
  24. Propacetamol versus ketorolac for treatment of acute postoperative pain after total hip or knee replacement. Zhou, T.J., Tang, J., White, P.F. Anesth. Analg. (2001) [Pubmed]
  25. Continuous popliteal sciatic nerve block: an original technique to provide postoperative analgesia after foot surgery. Singelyn, F.J., Aye, F., Gouverneur, J.M. Anesth. Analg. (1997) [Pubmed]
  26. Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection. Mimoz, O., Incagnoli, P., Josse, C., Gillon, M.C., Kuhlman, L., Mirand, A., Soilleux, H., Fletcher, D. Anaesthesia. (2001) [Pubmed]
  27. Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates. Allegaert, K., de Hoon, J., Verbesselt, R., Vanhole, C., Devlieger, H., Tibboel, D. Acta Paediatr. (2005) [Pubmed]
  28. Adjunctive analgesia with intravenous propacetamol does not reduce morphine-related adverse effects. Aubrun, F., Kalfon, F., Mottet, P., Bellanger, A., Langeron, O., Coriat, P., Riou, B. British journal of anaesthesia. (2003) [Pubmed]
  29. The efficacy of continuous fascia iliaca compartment block for pain management in burn patients undergoing skin grafting procedures. Cuignet, O., Pirson, J., Boughrouph, J., Duville, D. Anesth. Analg. (2004) [Pubmed]
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