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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Etoposide microcrystals suspended in oil: a new dosage form to peritoneal carcinomatosis in mice.

Etoposide microcrystals suspended in oil ( ETOP-OIL) were examined for their therapeutic effects on peritoneal carcinomatosis in mice. Two days after intraperitoneal inoculation with 10(5) P388 leukemia cells/mouse to CDF1 male mice, etoposide at 10-80 mg/kg was administered intraperitoneally in bolus in the form of ETOP-OIL or in the aqueous solution form. In every dose, the survival curve of the mice given ETOP-OIL was statistically significantly improved in spite of its small lethal toxicity, as compared with those given the identical dose of etoposide aqueous solution.[1]

References

  1. Etoposide microcrystals suspended in oil: a new dosage form to peritoneal carcinomatosis in mice. Hagiwara, A., Takahashi, T., Sasabe, T., Ito, M., Lee, M., Sakakura, C., Shoubayashi, S., Tashima, S., Muranishi, S. Oncology (1992) [Pubmed]
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