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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A.

The heterotrimeric protein phosphatase 2A ( PP2A) complex comprises a catalytic subunit and regulatory A and B subunits that modulate enzyme activity and mediate interactions with other proteins. We report here the results of a systematic analysis of the Arabidopsis (Arabidopsis thaliana) regulatory A subunit gene family, which includes the ROOTS CURL IN NAPHTHYLPHTHALAMIC ACID1 (RCN1), PP2AA2, and PP2AA3 genes. All three A subunit isoforms accumulate in the organs of seedlings and adult plants, suggesting extensive overlap in expression domains. We have isolated pp2aa2 and pp2aa3 mutants and found that their phenotypes are largely normal and do not resemble that of rcn1. Whereas rcn1 pp2aa2 and rcn1 pp2aa3 double mutants exhibit striking abnormalities in all stages of development, the pp2aa2 pp2aa3 double mutant shows only modest defects. Together, these data suggest that RCN1 performs a cardinal role in regulation of phosphatase activity and that PP2AA2 and PP2AA3 functions are unmasked only when RCN1 is absent.[1]


  1. Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A. Zhou, H.W., Nussbaumer, C., Chao, Y., DeLong, A. Plant Cell (2004) [Pubmed]
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