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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.

Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. Here, we show that MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.[1]

References

  1. The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Matsuoka, T.A., Artner, I., Henderson, E., Means, A., Sander, M., Stein, R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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