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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Novel testis- and embryo-specific isoforms of the phosphofructokinase-1 muscle type gene.

We have identified novel transcriptional isoforms of the human and mouse genes encoding muscle type phosphofructokinase-1 (PFK-M). These isoforms are expressed specifically in the testis and in the mid-gestation embryo, and have been termed TE-PFK-M (testis- and embryo-specific PFK-M). The 5'UTR of TE-PFK-M is composed of three newly identified exons that lie much farther upstream of the PFK-M coding region than the previously characterized 5'UTR. In addition, this upstream region encodes a series of small polyadenylated transcripts, some of which share the same exons found in the 5'UTR of TE-PFK-M, and which may play some role in regulating TE-PFK-M expression. These findings indicate an even more complex level of control of PFK-M expression than previously thought.[1]

References

  1. Novel testis- and embryo-specific isoforms of the phosphofructokinase-1 muscle type gene. Yamada, S., Nakajima, H., Kuehn, M.R. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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