- The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Radstake, T.R., Franke, B., Hanssen, S., Netea, M.G., Welsing, P., Barrera, P., Joosten, L.A., van Riel, P.L., van den Berg, W.B. Arthritis Rheum. (2004)