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MeSH Review

Arthritis, Rheumatoid

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Disease relevance of Arthritis, Rheumatoid


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Chemical compound and disease context of Arthritis, Rheumatoid


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Gene context of Arthritis, Rheumatoid


Analytical, diagnostic and therapeutic context of Arthritis, Rheumatoid


  1. Beneficial autoimmunity to proinflammatory mediators restrains the consequences of self-destructive immunity. Wildbaum, G., Nahir, M.A., Karin, N. Immunity (2003) [Pubmed]
  2. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. Lafaille, J.J., Keere, F.V., Hsu, A.L., Baron, J.L., Haas, W., Raine, C.S., Tonegawa, S. J. Exp. Med. (1997) [Pubmed]
  3. Critical role for granulocyte colony-stimulating factor in inflammatory arthritis. Lawlor, K.E., Campbell, I.K., Metcalf, D., O'Donnell, K., van Nieuwenhuijze, A., Roberts, A.W., Wicks, I.P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy. Triantaphyllopoulos, K.A., Williams, R.O., Tailor, H., Chernajovsky, Y. Arthritis Rheum. (1999) [Pubmed]
  5. Association between HLA and Sjögren's syndrome in Japanese patients. Moriuchi, J., Ichikawa, Y., Takaya, M., Shimizu, H., Uchiyama, M., Sato, K., Tsuji, K., Arimori, S. Arthritis Rheum. (1986) [Pubmed]
  6. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Camps, M., Rückle, T., Ji, H., Ardissone, V., Rintelen, F., Shaw, J., Ferrandi, C., Chabert, C., Gillieron, C., Françon, B., Martin, T., Gretener, D., Perrin, D., Leroy, D., Vitte, P.A., Hirsch, E., Wymann, M.P., Cirillo, R., Schwarz, M.K., Rommel, C. Nat. Med. (2005) [Pubmed]
  7. Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation. Hu, X., Herrero, C., Li, W.P., Antoniv, T.T., Falck-Pedersen, E., Koch, A.E., Woods, J.M., Haines, G.K., Ivashkiv, L.B. Nat. Immunol. (2002) [Pubmed]
  8. Dynamic visualization of a joint-specific autoimmune response through positron emission tomography. Wipke, B.T., Wang, Z., Kim, J., McCarthy, T.J., Allen, P.M. Nat. Immunol. (2002) [Pubmed]
  9. Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. Honda, T., Segi-Nishida, E., Miyachi, Y., Narumiya, S. J. Exp. Med. (2006) [Pubmed]
  10. Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis. Ji, J.D., Tassiulas, I., Park-Min, K.H., Aydin, A., Mecklenbrauker, I., Tarakhovsky, A., Pricop, L., Salmon, J.E., Ivashkiv, L.B. J. Exp. Med. (2003) [Pubmed]
  11. Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. Storgard, C.M., Stupack, D.G., Jonczyk, A., Goodman, S.L., Fox, R.I., Cheresh, D.A. J. Clin. Invest. (1999) [Pubmed]
  12. Letter: Clotrimazole and rheumatoid arthritis. Otterness, I.G., Niblack, J.F. Lancet (1976) [Pubmed]
  13. Agalactosyl glycoforms of IgG autoantibodies are pathogenic. Rademacher, T.W., Williams, P., Dwek, R.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Toraldo, G., Roggia, C., Qian, W.P., Pacifici, R., Weitzmann, M.N. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis. Montesinos, M.C., Yap, J.S., Desai, A., Posadas, I., McCrary, C.T., Cronstein, B.N. Arthritis Rheum. (2000) [Pubmed]
  16. Quality appraisal of clinical practice guidelines and consensus statements on the use of biologic agents in rheumatoid arthritis: a systematic review. Lopez-Olivo, M.A., Kallen, M.A., Ortiz, Z., Skidmore, B., Suarez-Almazor, M.E. Arthritis Rheum. (2008) [Pubmed]
  17. Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Yumoto, K., Ishijima, M., Rittling, S.R., Tsuji, K., Tsuchiya, Y., Kon, S., Nifuji, A., Uede, T., Denhardt, D.T., Noda, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  18. Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt. Zhang, H.G., Wang, Y., Xie, J.F., Liang, X., Liu, D., Yang, P., Hsu, H.C., Ray, R.B., Mountz, J.D. Arthritis Rheum. (2001) [Pubmed]
  19. A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis. Otto, J.M., Chandrasekeran, R., Vermes, C., Mikecz, K., Finnegan, A., Rickert, S.E., Enders, J.T., Glant, T.T. J. Immunol. (2000) [Pubmed]
  20. The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome. Radstake, T.R., Franke, B., Hanssen, S., Netea, M.G., Welsing, P., Barrera, P., Joosten, L.A., van Riel, P.L., van den Berg, W.B. Arthritis Rheum. (2004) [Pubmed]
  21. Reliability and sensitivity to change of the OMERACT rheumatoid arthritis magnetic resonance imaging score in a multireader, longitudinal setting. Haavardsholm, E.A., Ostergaard, M., Ejbjerg, B.J., Kvan, N.P., Uhlig, T.A., Lilleås, F.G., Kvien, T.K. Arthritis Rheum. (2005) [Pubmed]
  22. Interleukin 6 is required for the development of collagen-induced arthritis. Alonzi, T., Fattori, E., Lazzaro, D., Costa, P., Probert, L., Kollias, G., De Benedetti, F., Poli, V., Ciliberto, G. J. Exp. Med. (1998) [Pubmed]
  23. The TRAIL to arthritis. Tsokos, G.C., Tsokos, M. J. Clin. Invest. (2003) [Pubmed]
  24. Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. Zhang, H., Yang, Y., Horton, J.L., Samoilova, E.B., Judge, T.A., Turka, L.A., Wilson, J.M., Chen, Y. J. Clin. Invest. (1997) [Pubmed]
  25. Interleukin-4 can be a key positive regulator of inflammatory arthritis. Ohmura, K., Nguyen, L.T., Locksley, R.M., Mathis, D., Benoist, C. Arthritis Rheum. (2005) [Pubmed]
  26. Correlation between anti-RANA and anti-EBNA titers in normal subjects with and without HLA-DRw4. Catalano, M.A., Carson, D.A., Stastny, P., Freer, S., Vaughan, J.H. Arthritis Rheum. (1980) [Pubmed]
  27. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. Han, Z., Boyle, D.L., Chang, L., Bennett, B., Karin, M., Yang, L., Manning, A.M., Firestein, G.S. J. Clin. Invest. (2001) [Pubmed]
  28. Paradoxical anti-inflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells. Zakharova, M., Ziegler, H.K. J. Immunol. (2005) [Pubmed]
  29. The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis. Itoh, T., Matsuda, H., Tanioka, M., Kuwabara, K., Itohara, S., Suzuki, R. J. Immunol. (2002) [Pubmed]
  30. Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase. Crandall, H., Ma, Y., Dunn, D.M., Sundsbak, R.S., Zachary, J.F., Olofsson, P., Holmdahl, R., Weis, J.H., Weiss, R.B., Teuscher, C., Weis, J.J. Am. J. Pathol. (2005) [Pubmed]
  31. TNF-alpha antibodies and osteoprotegerin decrease systemic bone loss associated with inflammation through distinct mechanisms in collagen-induced arthritis. Saidenberg-Kermanac'h, N., Corrado, A., Lemeiter, D., deVernejoul, M.C., Boissier, M.C., Cohen-Solal, M.E. Bone (2004) [Pubmed]
  32. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. Morita, Y., Yang, J., Gupta, R., Shimizu, K., Shelden, E.A., Endres, J., Mulé, J.J., McDonagh, K.T., Fox, D.A. J. Clin. Invest. (2001) [Pubmed]
  33. Therapeutic antibodies elicited by immunization against TNF-alpha. Dalum, I., Butler, D.M., Jensen, M.R., Hindersson, P., Steinaa, L., Waterston, A.M., Grell, S.N., Feldmann, M., Elsner, H.I., Mouritsen, S. Nat. Biotechnol. (1999) [Pubmed]
  34. Stromal cells and osteoclasts are responsible for exacerbated collagen-induced arthritis in interferon-beta-deficient mice. Treschow, A.P., Teige, I., Nandakumar, K.S., Holmdahl, R., Issazadeh-Navikas, S. Arthritis Rheum. (2005) [Pubmed]
  35. Serum antibody in rheumatoid arthritis reactive with a cell-associated antigen. Demonstration by precipitation and immunofluorescence. Aslpaugh, M.A., Tan, E.M. Arthritis Rheum. (1976) [Pubmed]
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