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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-alpha.

We investigated whether repression of JNK by hepatocyte growth factor/scatter factor ( HGF/SF) in MDCK epithelial cells is linked to its ability to protect cells from apoptosis. To this purpose, cells were treated by TNF-alpha, a well-known inducer of JNK and of cell death, and the effects of HGF/SF were investigated under these conditions. We identified repression of JNK as a signaling target of HGF/SF for protection against TNF-alpha-induced cell death. This effect of HGF/SF occurs via the activation of the PI3K and MEK1 pathways.[1]

References

  1. Inhibition of JNK by HGF/SF prevents apoptosis induced by TNF-alpha. Reveneau, S., Paumelle, R., Deheuninck, J., Leroy, C., De Launoit, Y., Fafeur, V. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
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