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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Two new diterpenoids from Ballota limbata.

Two new clerodane-type diterpenoids trivially named as ballotenic acid (1) and ballodiolic acid (2) have been isolated from Ballota limbata along with three the known compounds; beta-amyrin, oleanolic acid, and beta-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect (NOE) experiments. Compounds 1 and 2 displayed inhibitory potential against lipoxygenase enzyme in a concentration-dependent fashion with IC(50) values of 99.6 microM and 38.3 microM, respectively.[1]


  1. Two new diterpenoids from Ballota limbata. Ahmad, V.U., Farooq, U., Hussain, J., Ullah, F., Nawaz, S.A., Choudhary, M.I. Chem. Pharm. Bull. (2004) [Pubmed]
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