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Chemical Compound Review

Clionasterol     (8S,9S,10R,13R,14S,17R)-17- [(2R,5R)-5...

Synonyms: AG-G-04202, SureCN3128216, AC1L2JKH, NSC 8096, CTK1H1142, ...
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Disease relevance of Harzol


High impact information on Harzol


Chemical compound and disease context of Harzol


Biological context of Harzol

  • Segregation analysis of the sitosterol levels showed that the phenotype of sitosterolemia was controlled by a rare autosomal recessive gene [15].
  • Plasma cholesterol concentrations increased 120% in the sitosterol-infused rats and 29% in the untreated human homozygotes [16].
  • We investigated hepatic cholesterol homeostasis in four homozygous sitosterolemic subjects from two unrelated families who showed enhanced absorption, diminished removal and increased tissue and plasma concentrations of sitosterol (24-ethyl cholesterol) [16].
  • With recombinant high density lipoprotein particles, the esterification rate of cholesterol by LCAT was only 15% greater than for sitosterol [17].
  • However, whereas FC induces caspase-dependent apoptosis through activation of the unfolded protein response and JNK, sitosterol-induced death is caspase-independent and involves neither the unfolded protein response nor JNK [5].

Anatomical context of Harzol

  • As with FC loading, sitosterol-induced macrophage death requires sterol trafficking to the endoplasmic reticulum, and sitosterol-enriched endoplasmic reticulum membranes show evidence of membrane protein dysfunction [5].
  • In support of this hypothesis, we show here that macrophages incubated with sitosterol-containing lipoproteins accumulate free sterols and undergo death in the absence of an ACAT inhibitor [5].
  • More than 90% of these radiolabeled sterols underwent exchange at 37 degrees C with unlabeled sterols in vesicles over a period of 12-14 h in the presence of 2% (w/v) albumin. beta-[14C]Sitosterol exchange was characterized by biphasic exchange kinetics, indicative of two pools of sitosterol molecules in the cell membrane [18].
  • Compared with ACAT1, ACAT2 selectively esterified cholesterol even when sitosterol was loaded into the microsomes [17].
  • A recombinant StAR protein lacking the first N-terminal 62 amino acid residues that includes the mitochondrial targeting sequence was shown to stimulate the transfer of cholesterol and beta-sitosterol from liposomes to heat-treated mitochondria in a dose-, time-, and temperature-dependent manner [19].

Associations of Harzol with other chemical compounds


Gene context of Harzol


Analytical, diagnostic and therapeutic context of Harzol


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