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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Ballota

  • Quercus ilex L. subsp. ballota (Desf.) Samp., a Mediterranean evergreen species growing in a continental Mediterranean climate, did not experience water stress and showed greater sensitivity to winter stress than to summer stress over a 12-month period [1].

High impact information on Ballota

  • Two new clerodane-type diterpenoids trivially named as ballotenic acid (1) and ballodiolic acid (2) have been isolated from Ballota limbata along with three the known compounds; beta-amyrin, oleanolic acid, and beta-sitosterol [2].
  • The semi-synthetic transformation of hispanolone, isolated from Ballota africana, into 6beta-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one has established an ent-labdane absolute stereochemistry for a diterpene metabolite originally isolated from B. aucheri [3].
  • In the present study, the antioxidant properties of ethanol extracts of 16 Ballota species belonging to the Lamiaceae family and growing in Turkey on superoxide anion formation and lipid peroxidation were investigated [4].
  • Water extract of Ballota glandulosissima Hub.-Mor & Patzak (Lamiaceae) (BG) was investigated for anti-inflammatory activity using the carrageenan-induced rat paw oedema test and for hepatoprotective effect on carbon tetrachloride (CCl(4))-induced hepatotoxicity in rats [5].
  • The extracts of Ballota antalyense, Ballota macrodonta and Ballota glandulosissima have the lowest IC(50) values (0.50, 0.51 and 0.51 mg/ml, respectively) which were rather close to the well-known superoxide anion scavenger alpha-tocopherol (IC(50): 0.22 mg/ml) [4].

Associations of Ballota with chemical compounds

  • The goal of this study was to test whether the major polyphenolic compounds extracted from Ballota nigra, four phenylpropanoid glycosides, verbascoside, forsythoside B, arenarioside, and ballotetroside and one non-glycosidic phenylpropanoid, caffeoyl-L-malic acid, inhibit Cu(2+)-induced LDL peroxidation [6].

Gene context of Ballota


  1. Seasonal changes in photosynthesis and photoprotection in a Quercus ilex subsp. ballota woodland located in its upper altitudinal extreme in the Iberian Peninsula. Corcuera, L., Morales, F., Abadía, A., Gil-Pelegrín, E. Tree Physiol. (2005) [Pubmed]
  2. Two new diterpenoids from Ballota limbata. Ahmad, V.U., Farooq, U., Hussain, J., Ullah, F., Nawaz, S.A., Choudhary, M.I. Chem. Pharm. Bull. (2004) [Pubmed]
  3. The absolute stereochemistry of a diterpene from Ballota aucheri. Gray, C.A., Rivett, D.E., Davies-Coleman, M.T. Phytochemistry (2003) [Pubmed]
  4. Antioxidant properties of Ballota species growing in Turkey. Citoğlu, G.S., Coban, T., Sever, B., Işcan, M. Journal of ethnopharmacology. (2004) [Pubmed]
  5. Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima. Ozbek, H., Citoğlu, G.S., Dülger, H., Uğraş, S., Sever, B. Journal of ethnopharmacology. (2004) [Pubmed]
  6. Phenylpropanoids from Ballota nigra L. inhibit in vitro LDL peroxidation. Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J.C., Duriez, P., Bailleul, F., Teissier, E. Phytotherapy research : PTR. (2000) [Pubmed]
  7. Neurosedative and antioxidant activities of phenylpropanoids from ballota nigra. Daels-Rakotoarison, D.A., Seidel, V., Gressier, B., Brunet, C., Tillequin, F., Bailleul, F., Luyckx, M., Dine, T., Cazin, M., Cazin, J.C. Arzneimittel-Forschung. (2000) [Pubmed]
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