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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Notch signaling in lymphocyte development and function.

Over the past few years, the crucial role of Notch signaling in multiple stages of T-cell development has become apparent. Recent studies have helped to define more precisely the functions and components of the Notch signaling pathway in T-cell development, including during the T versus B fate decision and in early CD4(-)CD8(-)double-negative thymocytes. In addition, new evidence points to a requirement for Notch2 in the development of marginal zone B cells. Finally, recent studies have provided our first glimpse into the complex and paradoxical roles of Notch signaling in the activation and differentiation of mature T cells.[1]


  1. Notch signaling in lymphocyte development and function. Robey, E.A., Bluestone, J.A. Curr. Opin. Immunol. (2004) [Pubmed]
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