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Shankaran, K. et al.

Shankaran, Donnelly, Shah, Caldwell, Chen, Finke, Oates, MacCoss, Mills, DeMartino, Gould, Malkowitz, Siciliano, Springer, Kwei, Carella, Carver, Danzeisen, Hazuda, Holmes, Kessler, Lineberger, Miller, Emini, Schleif,

Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.

Cellular proliferation of HIV-1 requires the cooperative assistance of both the CCR5 and CD4 receptors. Our medicinal chemistry efforts in this area have resulted in the identification of N-alkyl piperidine sulfones as CCR5 antagonists. These compounds display potent binding and show antiviral properties in HIV-1 spread cell-based assays.[1]

References

Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists. Shankaran, K., Donnelly, K.L., Shah, S.K., Caldwell, C.G., Chen, P., Finke, P.E., Oates, B., MacCoss, M., Mills, S.G., DeMartino, J.A., Gould, S.L., Malkowitz, L., Siciliano, S.J., Springer, M.S., Kwei, G., Carella, A., Carver, G., Danzeisen, R., Hazuda, D., Holmes, K., Kessler, J., Lineberger, J., Miller, M.D., Emini, E.A., Schleif, W.A. Bioorg. Med. Chem. Lett. (2004) [Pubmed]

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