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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth.

In the present study, we reported on the synthesis of two new mu-opioid peptide analogs, [D-1-Nal3]morphiceptin and [D-1-Nal4]-morphiceptin [1-Nal=3-(1-naphthyl)-alanine] which expressed receptor binding affinities at least at the level of the primary opioid ligands. The new analogs also labeled mu-opioid receptors on the cells of human breast cancer MCF-7 cell line with affinity much higher than that of endomorphins and morphiceptin, the well-known mu-selective opioid peptides. However, none of the tested peptides significantly decreased cell proliferation of MCF-7 cells.[1]

References

  1. Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth. Janecka, A., Fichna, J., Kosson, P., Zalewska-Kaszubska, J., Krajewska, U., Mirowski, M., Rozalski, M. Regul. Pept. (2004) [Pubmed]
 
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