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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Serodiagnostic studies in an immunocompetent individual infected with Encephalitozoon cuniculi.

Little is known about the prevalence and clinical significance of infection with Encephalitozoon species in immunocompetent individuals. In the present study, by using indirect immunofluorescence technique (IFAT), Western blot, and recombinant antigens of the spore wall (SWP1) and polar tube (PTP1, PTP2, and PTP3 ), we analyzed the IgG antibody response of a laboratory worker who was infected with Encephalitozoon cuniculi. Serum samples were analyzed 1, 20, 32, and 38 months after infection. After 1 month, by use of IFAT, only spore-wall antigens were recognized, an antibody reaction that changed toward both the spore wall and polar tube in the following months. By use of Western blot analysis, a characteristic pattern that recognized multiple bands was noticed. Reaction against SWP1 was present in all 4 serum samples. The IgG response against PTP1, PTP2, and PTP3 was not detectable 1 month after infection, but became evident in the follow-up serum samples. Serum samples showed cross-reactivity with the spore wall of Encephalitozoon hellem and Encephalitozoon intestinalis, but only little cross-reactivity with the polar tube of these parasites. This is the first study to our knowledge that provides full details about the antibody response against a specified Encephalitozoon species in an immunocompetent person. The results strongly encourage the development and use of reliable serodiagnostic methods, which will provide information about the prevalence and clinical significance of Encephalitozoon species infection in humans.[1]


  1. Serodiagnostic studies in an immunocompetent individual infected with Encephalitozoon cuniculi. van Gool, T., Biderre, C., Delbac, F., Wentink-Bonnema, E., Peek, R., Vivarès, C.P. J. Infect. Dis. (2004) [Pubmed]
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