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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Encephalitozoon


High impact information on Encephalitozoon


Chemical compound and disease context of Encephalitozoon


Biological context of Encephalitozoon


Anatomical context of Encephalitozoon

  • The efficacy of fenbendazole for preventing an experimental infection of Encephalitozoon cuniculi and for eliminating the spores from the central nervous system of naturally infected rabbits was investigated [15].
  • Spores of the microsporidian parasitic protozoan Encephalitozoon hellem were purified and incubated at 37 degrees C in a solution with an electrolyte composition similar to that of mammalian extracellular fluid, and in solution in which the calcium had been replaced with 0.2 mM EGTA [16].

Associations of Encephalitozoon with chemical compounds


Gene context of Encephalitozoon

  • An encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1 [22].
  • Resistance to Encephalitozoon intestinalis is associated with interferon-gamma and interleukin-2 cytokines in infected mice [23].
  • Polymerase chain reaction and culture confirmation of disseminated Encephalitozoon cuniculi in a patient with AIDS: successful therapy with albendazole [24].
  • Encephalitozoon (Septata) intestinalis affects AIDS patients with CD4 counts <100/microL, causing intestinal and disseminated disease [25].
  • Seven isolates of Encephalitozoon hellem from human immunodeficiency virus-positive patients were genotyped through a series of markers: the internal transcribed spacer (ITS) of ribosomal DNA, the polar tube protein (PTP) gene, and two intergenic spacers (IGS-TH and IGS-HZ) whose polymorphism is newly reported [26].

Analytical, diagnostic and therapeutic context of Encephalitozoon


  1. Effects of albendazole, fumagillin, and TNP-470 on microsporidial replication in vitro. Didier, E.S. Antimicrob. Agents Chemother. (1997) [Pubmed]
  2. Polyclonal and monoclonal antibody and PCR-amplified small-subunit rRNA identification of a microsporidian, Encephalitozoon hellem, isolated from an AIDS patient with disseminated infection. Visvesvara, G.S., Leitch, G.J., da Silva, A.J., Croppo, G.P., Moura, H., Wallace, S., Slemenda, S.B., Schwartz, D.A., Moss, D., Bryan, R.T. J. Clin. Microbiol. (1994) [Pubmed]
  3. A patient with acquired immunodeficiency syndrome and untreated Encephalitozoon (Septata) intestinalis microsporidiosis leading to small bowel perforation. Response to albendazole. Soule, J.B., Halverson, A.L., Becker, R.B., Pistole, M.C., Orenstein, J.M. Arch. Pathol. Lab. Med. (1997) [Pubmed]
  4. Susceptibility of IFN-gamma or IL-12 knock-out and SCID mice to infection with two microsporidian species, Encephalitozoon cuniculi and E. intestinalis. Salát, J., Sak, B., Le, T., Kopecký, J. Folia Parasitol. (2004) [Pubmed]
  5. Thalidomide: a novel therapy for microsporidiosis. Sharpstone, D., Rowbottom, A., Francis, N., Tovey, G., Ellis, D., Barrett, M., Gazzard, B. Gastroenterology (1997) [Pubmed]
  6. Human microsporidial infections. Weber, R., Bryan, R.T., Schwartz, D.A., Owen, R.L. Clin. Microbiol. Rev. (1994) [Pubmed]
  7. Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. Hausmann, S., Zheng, S., Fabrega, C., Schneller, S.W., Lima, C.D., Shuman, S. J. Biol. Chem. (2005) [Pubmed]
  8. Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA. Zhu, Y., Stribinskis, V., Ramos, K.S., Li, Y. RNA (2006) [Pubmed]
  9. Overt fatal and chronic subclinical Encephalitozoon cuniculi microsporidiosis in a colony of captive emperor tamarins (Saguinus imperator). Guscetti, F., Mathis, A., Hatt, J.M., Deplazes, P. J. Med. Primatol. (2003) [Pubmed]
  10. Glycosylation of the major polar tube protein of Encephalitozoon hellem, a microsporidian parasite that infects humans. Xu, Y., Takvorian, P.M., Cali, A., Orr, G., Weiss, L.M. Infect. Immun. (2004) [Pubmed]
  11. Serodiagnostic studies in an immunocompetent individual infected with Encephalitozoon cuniculi. van Gool, T., Biderre, C., Delbac, F., Wentink-Bonnema, E., Peek, R., Vivarès, C.P. J. Infect. Dis. (2004) [Pubmed]
  12. Phylogenetic relationships of methionine aminopeptidase 2 among Encephalitozoon species and genotypes of microsporidia. Pandrea, I., Mittleider, D., Brindley, P.J., Didier, E.S., Robertson, D.L. Mol. Biochem. Parasitol. (2005) [Pubmed]
  13. Nucleotide sequences of DNA fragments of Encephalitozoon cuniculi amplified by polymerase chain reaction with primers regarded as specific for Echinococcus. Nagano, H., Satoh, C., Furuya, K. J. Eukaryot. Microbiol. (1996) [Pubmed]
  14. RNA-binding domain proteins in Kinetoplastids: a comparative analysis. De Gaudenzi, J., Frasch, A.C., Clayton, C. Eukaryotic Cell (2005) [Pubmed]
  15. Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazole. Suter, C., Müller-Doblies, U.U., Hatt, J.M., Deplazes, P. Vet. Rec. (2001) [Pubmed]
  16. Inhibition of the spore polar filament extrusion of the microsporidium, Encephalitozoon hellem, isolated from an AIDS patient. Leitch, G.J., He, Q., Wallace, S., Visvesvara, G.S. J. Eukaryot. Microbiol. (1993) [Pubmed]
  17. In vitro efficacy of nikkomycin Z against the human isolate of the microsporidian species Encephalitozoon hellem. Bigliardi, E., Bernuzzi, A.M., Corona, S., Gatti, S., Scaglia, M., Sacchi, L. Antimicrob. Agents Chemother. (2000) [Pubmed]
  18. In vitro effects of resveratrol on the viability and infectivity of the microsporidian Encephalitozoon cuniculi. Leiro, J., Cano, E., Ubeira, F.M., Orallo, F., Sanmartín, M.L. Antimicrob. Agents Chemother. (2004) [Pubmed]
  19. Developmental expression of a tandemly repeated, glycine- and serine-rich spore wall protein in the microsporidian pathogen Encephalitozoon cuniculi. Bohne, W., Ferguson, D.J., Kohler, K., Gross, U. Infect. Immun. (2000) [Pubmed]
  20. In vitro susceptibilities of the microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to albendazole and its sulfoxide and sulfone metabolites. Ridoux, O., Drancourt, M. Antimicrob. Agents Chemother. (1998) [Pubmed]
  21. Microsporidian invasion apparatus: identification of a novel polar tube protein and evidence for clustering of ptp1 and ptp2 genes in three Encephalitozoon species. Delbac, F., Peuvel, I., Metenier, G., Peyretaillade, E., Vivares, C.P. Infect. Immun. (2001) [Pubmed]
  22. An encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1. Hausmann, S., Schwer, B., Shuman, S. Biochemistry (2004) [Pubmed]
  23. Resistance to Encephalitozoon intestinalis is associated with interferon-gamma and interleukin-2 cytokines in infected mice. El Fakhry, Y., Achbarou, A., Desportes, I., Mazier, D. Parasite Immunol. (2001) [Pubmed]
  24. Polymerase chain reaction and culture confirmation of disseminated Encephalitozoon cuniculi in a patient with AIDS: successful therapy with albendazole. De Groote, M.A., Visvesvara, G., Wilson, M.L., Pieniazek, N.J., Slemenda, S.B., daSilva, A.J., Leitch, G.J., Bryan, R.T., Reves, R. J. Infect. Dis. (1995) [Pubmed]
  25. Encephalitozoon (Septata) intestinalis: cytologic, histologic, and electron microscopic features of a systemic intestinal pathogen. Chu, P., West, A.B. Am. J. Clin. Pathol. (1996) [Pubmed]
  26. Intraspecies genotype variability of the microsporidian parasite Encephalitozoon hellem. Haro, M., Del Aguila, C., Fenoy, S., Henriques-Gil, N. J. Clin. Microbiol. (2003) [Pubmed]
  27. Effects of nifedipine, metronidazole, and nitric oxide donors on spore germination and cell culture infection of the microsporidia Encephalitozoon hellem and Encephalitozoon intestinalis. He, Q., Leitch, G.J., Visvesvara, G.S., Wallace, S. Antimicrob. Agents Chemother. (1996) [Pubmed]
  28. Detection by an immunofluorescence test of Encephalitozoon intestinalis spores in routinely formalin-fixed stool samples stored at room temperature. Moura, H., Sodre, F.C., Bornay-Llinares, F.J., Leitch, G.J., Navin, T., Wahlquist, S., Bryan, R., Meseguer, I., Visvesvara, G.S. J. Clin. Microbiol. (1999) [Pubmed]
  29. Immunocytochemical identification of spore proteins in two microsporidia, with emphasis on extrusion apparatus. Delbac, F., Duffieux, F., David, D., Metenier, G., Vivares, C.P. J. Eukaryot. Microbiol. (1998) [Pubmed]
  30. Evidence of actin in the cytoskeleton of microsporidia. Bigliardi, E., Riparbelli, M.G., Selmi, M.G., Bini, L., Liberatori, S., Pallini, V., Bernuzzi, A., Gatti, S., Scaglia, M., Sacchi, L. J. Eukaryot. Microbiol. (1999) [Pubmed]
  31. An indirect ELISA for detection of Encephalitozoon cuniculi infection in farmed blue foxes (Alopex lagopus). Akerstedt, J. Acta Vet. Scand. (2002) [Pubmed]
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