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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Suitability of bupropion SR for nicotine-dependent smokers: problems in a practice setting.

BACKGROUND: Bupropion SR (Zyban) has been shown in randomized controlled trials to be an efficacious pharmacological aid for smoking cessation; however, recent reports have raised serious concerns about the breadth of its applicability without complications or contraindications. METHODS: We examined this issue in a well-documented medical population, i.e. veterans volunteering to participate in a smoking cessation treatment research program involving the use of bupropion SR. RESULTS: Overall, 22% of the 78 subjects who met the study criteria were appropriate for and completed the course of medication. CONCLUSIONS: Thus, bupropion SR in nicotine-dependent veterans may not be broadly applicable when conservative prescribing guidelines are carefully followed.[1]

References

  1. Suitability of bupropion SR for nicotine-dependent smokers: problems in a practice setting. Kohlenberg, B.S., Antonuccio, D.O., Hayes, S.C., Gifford, E.V., Piasecki, M.P. Psychotherapy and psychosomatics. (2004) [Pubmed]
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