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MeSH Review

Smoking Cessation

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Disease relevance of Smoking Cessation


Psychiatry related information on Smoking Cessation


High impact information on Smoking Cessation


Chemical compound and disease context of Smoking Cessation


Biological context of Smoking Cessation


Anatomical context of Smoking Cessation

  • When subjects were divided according to their current smoking status, levels of sTNF-R55, sTNF-R75, and IL-8 in sputum were significantly elevated in ex-smoking versus currently smoking patients with COPD, suggesting ongoing inflammation in airways and circulation of patients with COPD after smoking cessation [27].
  • OBJECTIVE: The purpose of the present study was to investigate the effect of smoking cessation on the peripheral neutrophil mRNA expression levels for inflammatory cytokines, chemokine, growth factor and matrix metalloproteinase (MMP) [28].
  • Our data indicate that smoking cessation is associated with a significant decrease in the symptomatology of COPD, and that change in T lymphocyte beta 2-receptor density is a good marker of change in pulmonary response to beta 2-agonists [29].
  • The reactivity of the brachial artery was evaluated using flow-mediated dilation immediately after smoking cessation, before the application of a 21-mg nicotine patch or placebo patch, and 24 hours after patch placement [30].
  • Bupropion sustained release (SR) is the first non-nicotine pharmacological treatment approved for smoking cessation and is thought to be effective because of its dopaminergic activity on the pleasure and reward pathways in the mesolimbic system and nucleus accumbens [31].

Gene context of Smoking Cessation


Analytical, diagnostic and therapeutic context of Smoking Cessation


  1. The effect of nicotine on energy expenditure during light physical activity. Perkins, K.A., Epstein, L.H., Marks, B.L., Stiller, R.L., Jacob, R.G. N. Engl. J. Med. (1989) [Pubmed]
  2. Conservative management of intermittent claudication. Radack, K., Wyderski, R.J. Ann. Intern. Med. (1990) [Pubmed]
  3. Expected gains in life expectancy from various coronary heart disease risk factor modifications. Tsevat, J., Weinstein, M.C., Williams, L.W., Tosteson, A.N., Goldman, L. Circulation (1991) [Pubmed]
  4. Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Belinsky, S.A., Palmisano, W.A., Gilliland, F.D., Crooks, L.A., Divine, K.K., Winters, S.A., Grimes, M.J., Harms, H.J., Tellez, C.S., Smith, T.M., Moots, P.P., Lechner, J.F., Stidley, C.A., Crowell, R.E. Cancer Res. (2002) [Pubmed]
  5. Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease: the Lung Health Study. Kanner, R.E., Connett, J.E., Williams, D.E., Buist, A.S. Am. J. Med. (1999) [Pubmed]
  6. Effect of nicotine chewing gum in smoking cessation. A randomized, placebo-controlled, double-blind study. Hjalmarson, A.I. JAMA (1984) [Pubmed]
  7. Lung cancer risk reduction after smoking cessation: observations from a prospective cohort of women. Ebbert, J.O., Yang, P., Vachon, C.M., Vierkant, R.A., Cerhan, J.R., Folsom, A.R., Sellers, T.A. J. Clin. Oncol. (2003) [Pubmed]
  8. Effect of buspirone on withdrawal symptoms associated with smoking cessation. Hilleman, D.E., Mohiuddin, S.M., Del Core, M.G., Sketch, M.H. Arch. Intern. Med. (1992) [Pubmed]
  9. The effect of clonidine on the cessation of cigarette smoking. Davison, R., Kaplan, K., Fintel, D., Parker, M., Anderson, L., Haring, O. Clin. Pharmacol. Ther. (1988) [Pubmed]
  10. A placebo controlled trial of bupropion for smoking cessation in schizophrenia. George, T.P., Vessicchio, J.C., Termine, A., Bregartner, T.A., Feingold, A., Rounsaville, B.J., Kosten, T.R. Biol. Psychiatry (2002) [Pubmed]
  11. Lack of efficacy of transdermal nicotine in smoking cessation. Joseph, A.M., Antonnucio, D.O. N. Engl. J. Med. (1999) [Pubmed]
  12. A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. Jorenby, D.E., Leischow, S.J., Nides, M.A., Rennard, S.I., Johnston, J.A., Hughes, A.R., Smith, S.S., Muramoto, M.L., Daughton, D.M., Doan, K., Fiore, M.C., Baker, T.B. N. Engl. J. Med. (1999) [Pubmed]
  13. A comparison of sustained-release bupropion and placebo for smoking cessation. Hurt, R.D., Sachs, D.P., Glover, E.D., Offord, K.P., Johnston, J.A., Dale, L.C., Khayrallah, M.A., Schroeder, D.R., Glover, P.N., Sullivan, C.R., Croghan, I.T., Sullivan, P.M. N. Engl. J. Med. (1997) [Pubmed]
  14. The impact on infant birth weight and gestational age of cotinine-validated smoking reduction during pregnancy. Li, C.Q., Windsor, R.A., Perkins, L., Goldenberg, R.L., Lowe, J.B. JAMA (1993) [Pubmed]
  15. Randomized, controlled trial of clonidine for smoking cessation in a primary care setting. Franks, P., Harp, J., Bell, B. JAMA (1989) [Pubmed]
  16. Sustained-release bupropion for smoking cessation. Pasternak, M. N. Engl. J. Med. (1998) [Pubmed]
  17. A randomized trial of a family physician intervention for smoking cessation. Wilson, D.M., Taylor, D.W., Gilbert, J.R., Best, J.A., Lindsay, E.A., Willms, D.G., Singer, J. JAMA (1988) [Pubmed]
  18. Clonidine, depression, and smoking cessation. Hughes, J.R. JAMA (1988) [Pubmed]
  19. Sustained-release bupropion for smoking cessation in African Americans: a randomized controlled trial. Ahluwalia, J.S., Harris, K.J., Catley, D., Okuyemi, K.S., Mayo, M.S. JAMA (2002) [Pubmed]
  20. Involvement of the endocannabinoid system in drug addiction. Maldonado, R., Valverde, O., Berrendero, F. Trends Neurosci. (2006) [Pubmed]
  21. Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study. Mamede, M., Ishizu, K., Ueda, M., Mukai, T., Iida, Y., Kawashima, H., Fukuyama, H., Togashi, K., Saji, H. J. Nucl. Med. (2007) [Pubmed]
  22. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Tashkin, D.P., Altose, M.D., Connett, J.E., Kanner, R.E., Lee, W.W., Wise, R.A. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  23. Evidence of transient heart rate change after smoking cessation. Ward, K.D., Garvey, A.J., Bliss, R.E. Psychopharmacology (Berl.) (1992) [Pubmed]
  24. Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement. Chaudhri, N., Caggiula, A.R., Donny, E.C., Palmatier, M.I., Liu, X., Sved, A.F. Psychopharmacology (Berl.) (2006) [Pubmed]
  25. GP prescribing of nicotine replacement and bupropion to aid smoking cessation in England and Wales. McEwen, A., West, R., Owen, L. Addiction (2004) [Pubmed]
  26. The efficacy of nicotine gum in group-centered smoking cessation therapy in a family practice. Oswald, J.S., Worden, W.L., Cox, J.L. The Journal of family practice. (1988) [Pubmed]
  27. Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. Vernooy, J.H., Küçükaycan, M., Jacobs, J.A., Chavannes, N.H., Buurman, W.A., Dentener, M.A., Wouters, E.F. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  28. Alterations of gene expression in human neutrophils induced by smoking cessation. Morozumi, T., Kubota, T., Sugita, N., Itagaki, M., Yoshie, H. Journal of clinical periodontology. (2004) [Pubmed]
  29. Symptomatology, pulmonary function and response, and T lymphocyte beta 2-receptors during smoking cessation in patients with chronic obstructive pulmonary disease. Leader, W.G., Wolf, K.M., Cooper, T.M., Chandler, M.H. Pharmacotherapy (1994) [Pubmed]
  30. Blood pressure circadian rhythm and endothelial function in heavy smokers: acute effects of transdermal nicotine. Yugar-Toledo, J.C., Ferreira-Melo, S.E., Sabha, M., Nogueira, E.A., Coelho, O.R., Consolin Colombo, F.M., Irigoyen, M.C., Moreno, H. Journal of clinical hypertension (Greenwich, Conn.) (2005) [Pubmed]
  31. New medications for nicotine dependence treatment. Hurt, R.D. Nicotine Tob. Res. (1999) [Pubmed]
  32. A reversible monoamine oxidase A inhibitor (moclobemide) facilitates smoking cessation and abstinence in heavy, dependent smokers. Berlin, I., Saïd, S., Spreux-Varoquaux, O., Launay, J.M., Olivares, R., Millet, V., Lecrubier, Y., Puech, A.J. Clin. Pharmacol. Ther. (1995) [Pubmed]
  33. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Miksys, S., Lerman, C., Shields, P.G., Mash, D.C., Tyndale, R.F. Neuropharmacology (2003) [Pubmed]
  34. The effect of cigarette smoking use and cessation on serum insulin-like growth factors. Renehan, A.G., Atkin, W.S., O'dwyer, S.T., Shalet, S.M. Br. J. Cancer (2004) [Pubmed]
  35. Nicotine withdrawal induces subsensitivity of hypothalamic-pituitary-adrenal axis to stress in rats: implications for precipitation of depression during smoking cessation. Semba, J., Wakuta, M., Maeda, J., Suhara, T. Psychoneuroendocrinology (2004) [Pubmed]
  36. Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation. Silagy, C., Mant, D., Fowler, G., Lodge, M. Lancet (1994) [Pubmed]
  37. Quality of medical care and excess mortality in older patients with mental disorders. Druss, B.G., Bradford, W.D., Rosenheck, R.A., Radford, M.J., Krumholz, H.M. Arch. Gen. Psychiatry (2001) [Pubmed]
  38. Chronic obstructive pulmonary disease: is there a case for early intervention? Ramsey, S.D., Sullivan, S.D. Am. J. Med. (2004) [Pubmed]
  39. Current approaches to the management of smoking cessation. Sutherland, G. Drugs (2002) [Pubmed]
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