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MeSH Review

Randomized Controlled Trials

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Disease relevance of Randomized Controlled Trials


Psychiatry related information on Randomized Controlled Trials


High impact information on Randomized Controlled Trials

  • For the bile acid sequestrants, niacin, and gemfibrozil, the risks of discontinuation were substantially higher in the HMOs than in randomized clinical trials, in which the summary estimates of this risk were 31 percent, 4 percent, and 15 percent, respectively, for trials of one year or longer [11].
  • The weight of the evidence from randomized controlled trials of estrogen and cognition in women shows that this hormone preferentially protects verbal memory in postmenopausal women, whereas findings from observational studies are less consistent and show a more diffuse effect of estrogen on a range of cognitive functions [12].
  • Of 350 studies initially identified, 44 met inclusion criteria, including 36 randomized controlled trials and 8 controlled trials [13].
  • Whether lowering the homocysteine level reduces risk of cardiovascular events requires testing in randomized controlled trials [14].
  • Which approach to preventing rebleeding in the better-risk patient is more effective, as well as the role of pharmacologic therapy with propranolol or other agents, remains to be settled by well-controlled randomized clinical trials [15].

Chemical compound and disease context of Randomized Controlled Trials


Biological context of Randomized Controlled Trials


Anatomical context of Randomized Controlled Trials


Associations of Randomized Controlled Trials with chemical compounds


Gene context of Randomized Controlled Trials


Analytical, diagnostic and therapeutic context of Randomized Controlled Trials


  1. Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis. Kozyrskyj, A.L., Hildes-Ripstein, G.E., Longstaffe, S.E., Wincott, J.L., Sitar, D.S., Klassen, T.P., Moffatt, M.E. JAMA (1998) [Pubmed]
  2. Long-term weight loss with sibutramine: a randomized controlled trial. Wirth, A., Krause, J. JAMA (2001) [Pubmed]
  3. Coronary heart disease mortality and adjuvant tamoxifen therapy. Costantino, J.P., Kuller, L.H., Ives, D.G., Fisher, B., Dignam, J. J. Natl. Cancer Inst. (1997) [Pubmed]
  4. Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas. Kensler, T.W., Egner, P.A., Wang, J.B., Zhu, Y.R., Zhang, B.C., Lu, P.X., Chen, J.G., Qian, G.S., Kuang, S.Y., Jackson, P.E., Gange, S.J., Jacobson, L.P., Muñoz, A., Groopman, J.D. Gastroenterology (2004) [Pubmed]
  5. Efficacy and cost of low-molecular-weight heparin compared with standard heparin for the prevention of deep vein thrombosis after total hip arthroplasty. Anderson, D.R., O'Brien, B.J., Levine, M.N., Roberts, R., Wells, P.S., Hirsh, J. Ann. Intern. Med. (1993) [Pubmed]
  6. Suicide rates in short-term randomized controlled trials of newer antidepressants. Hammad, T.A., Laughren, T.P., Racoosin, J.A. Journal of clinical psychopharmacology. (2006) [Pubmed]
  7. Suitability of bupropion SR for nicotine-dependent smokers: problems in a practice setting. Kohlenberg, B.S., Antonuccio, D.O., Hayes, S.C., Gifford, E.V., Piasecki, M.P. Psychotherapy and psychosomatics. (2004) [Pubmed]
  8. Efficacy of rivastigmine in Alzheimer's disease patients with rapid disease progression: results of a meta-analysis. Farlow, M.R., Small, G.W., Quarg, P., Krause, A. Dementia and geriatric cognitive disorders. (2005) [Pubmed]
  9. Selective serotonin reuptake inhibitors in the treatment of post-traumatic stress disorder: a meta-analysis of randomized controlled trials. Stein, D.J., Seedat, S., van der Linden, G.J., Zungu-Dirwayi, N. International clinical psychopharmacology. (2000) [Pubmed]
  10. Hormone replacement therapy and cognitive performance: the role of homocysteine. Whitmer, R.A., Haan, M.N., Miller, J.W., Yaffe, K. J. Gerontol. A Biol. Sci. Med. Sci. (2003) [Pubmed]
  11. Discontinuation of antihyperlipidemic drugs--do rates reported in clinical trials reflect rates in primary care settings? Andrade, S.E., Walker, A.M., Gottlieb, L.K., Hollenberg, N.K., Testa, M.A., Saperia, G.M., Platt, R. N. Engl. J. Med. (1995) [Pubmed]
  12. Estrogen and cognitive functioning in women. Sherwin, B.B. Endocr. Rev. (2003) [Pubmed]
  13. Interventions for the treatment and management of chronic fatigue syndrome: a systematic review. Whiting, P., Bagnall, A.M., Sowden, A.J., Cornell, J.E., Mulrow, C.D., Ramírez, G. JAMA (2001) [Pubmed]
  14. Homocysteine and risk of cardiovascular disease among postmenopausal women. Ridker, P.M., Manson, J.E., Buring, J.E., Shih, J., Matias, M., Hennekens, C.H. JAMA (1999) [Pubmed]
  15. Management of the patient with hemorrhaging esophageal varices. Cello, J.P., Crass, R.A., Grendell, J.H., Trunkey, D.D. JAMA (1986) [Pubmed]
  16. Cholesterol screening in asymptomatic adults, revisited. Part 2. Garber, A.M., Browner, W.S., Hulley, S.B. Ann. Intern. Med. (1996) [Pubmed]
  17. Somatostatin or octreotide compared with H2 antagonists and placebo in the management of acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis. Imperiale, T.F., Birgisson, S. Ann. Intern. Med. (1997) [Pubmed]
  18. Ursodiol for hepatobiliary disorders. Rubin, R.A., Kowalski, T.E., Khandelwal, M., Malet, P.F. Ann. Intern. Med. (1994) [Pubmed]
  19. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death. Sim, I., McDonald, K.M., Lavori, P.W., Norbutas, C.M., Hlatky, M.A. Circulation (1997) [Pubmed]
  20. Meta-analysis of randomized clinical trials comparing Cisplatin to Carboplatin in patients with advanced non-small-cell lung cancer. Hotta, K., Matsuo, K., Ueoka, H., Kiura, K., Tabata, M., Tanimoto, M. J. Clin. Oncol. (2004) [Pubmed]
  21. Is epsilon-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery?: a meta-analysis. Munoz, J.J., Birkmeyer, N.J., Birkmeyer, J.D., O'Connor, G.T., Dacey, L.J. Circulation (1999) [Pubmed]
  22. A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors. Chiquette, E., Ramirez, G., Defronzo, R. Arch. Intern. Med. (2004) [Pubmed]
  23. Meta-analysis of randomized controlled trials of simplified versus continued protease inhibitor-based antiretroviral therapy in HIV-1-infected patients. Bucher, H.C., Kofler, A., Nüesch, R., Young, J., Battegay, M., Opravil, M. AIDS (2003) [Pubmed]
  24. Autoimmunity, immunoglobulin adsorption and dilated cardiomyopathy: has the time come for randomized clinical trials? Mann, D.L. J. Am. Coll. Cardiol. (2001) [Pubmed]
  25. Review: aromatase inhibitors for ovulation induction. Casper, R.F., Mitwally, M.F. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  26. Angiotensin-converting enzyme inhibitors in patients with coronary artery disease and absence of heart failure or left ventricular systolic dysfunction: an overview of long-term randomized controlled trials. Danchin, N., Cucherat, M., Thuillez, C., Durand, E., Kadri, Z., Steg, P.G. Arch. Intern. Med. (2006) [Pubmed]
  27. Perioperative epoetin alfa increases red blood cell mass and reduces exposure to transfusions: results of randomized clinical trials. Goldberg, M.A. Semin. Hematol. (1997) [Pubmed]
  28. Nutritional supplementation for stable chronic obstructive pulmonary disease. Ferreira, I.M., Brooks, D., Lacasse, Y., Goldstein, R.S., White, J. Cochrane database of systematic reviews (Online) (2002) [Pubmed]
  29. Comparative studies of multiple-dose cefoxitin vs. single-dose cefonicid for surgical prophylaxis in patients undergoing biliary tract operations or hysterectomy. Maki, D.G., Lammers, J.L., Aughey, D.R. Rev. Infect. Dis. (1984) [Pubmed]
  30. Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection. Oatway, C., Gunby, J., Daya, S. Cochrane database of systematic reviews (Online) (2004) [Pubmed]
  31. Development of matrix metalloproteinase inhibitors in cancer therapy. Hidalgo, M., Eckhardt, S.G. J. Natl. Cancer Inst. (2001) [Pubmed]
  32. Sulfasalazine revisited: a meta-analysis of 5-aminosalicylic acid in the treatment of ulcerative colitis. Sutherland, L.R., May, G.R., Shaffer, E.A. Ann. Intern. Med. (1993) [Pubmed]
  33. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Eikelboom, J.W., Lonn, E., Genest, J., Hankey, G., Yusuf, S. Ann. Intern. Med. (1999) [Pubmed]
  34. Risk factors for nephrotoxicity in patients treated with aminoglycosides. Moore, R.D., Smith, C.R., Lipsky, J.J., Mellits, E.D., Lietman, P.S. Ann. Intern. Med. (1984) [Pubmed]
  35. A prospective study of efficacy and safety of once-daily saquinavir/ritonavir plus two nucleoside reverse transcriptase inhibitors in treatment-naive Thai patients. Ananworanich, J., Hill, A., Siangphoe, U., Ruxrungtham, K., Prasithsirikul, W., Chetchotisakd, P., Kiertiburanakul, S., Munsakul, W., Raksakulkarn, P., Tansuphasawadikul, S., Nuesch, R., Cooper, D.A., Hirschel, B. Antivir. Ther. (Lond.) (2005) [Pubmed]
  36. Long-term efficacy and safety of etanercept after readministration in patients with active ankylosing spondylitis. Brandt, J., Listing, J., Haibel, H., Sörensen, H., Schwebig, A., Rudwaleit, M., Sieper, J., Braun, J. Rheumatology (Oxford, England) (2005) [Pubmed]
  37. Ongoing and planned trials of hormonal therapy and trastuzumab. Nicholson, B.P. Semin. Oncol. (2000) [Pubmed]
  38. Response to etanercept (Enbrel) in elderly patients with rheumatoid arthritis: a retrospective analysis of clinical trial results. Fleischmann, R.M., Baumgartner, S.W., Tindall, E.A., Weaver, A.L., Moreland, L.W., Schiff, M.H., Martin, R.W., Spencer-Green, G.T. J. Rheumatol. (2003) [Pubmed]
  39. A perspective on anti-cytokine and anti-T cell-directed therapies in rheumatoid arthritis. Maini, R.N. Clinical and experimental rheumatology. (1995) [Pubmed]
  40. Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis. Sørensen, T.L., Sellebjerg, F., Jensen, C.V., Strieter, R.M., Ransohoff, R.M. Eur. J. Neurol. (2001) [Pubmed]
  41. Phase II study of area under the plasma-concentration-versus-time curve-based carboplatin plus standard-dose intravenous etoposide in elderly patients with small-cell lung cancer. Okamoto, H., Watanabe, K., Nishiwaki, Y., Mori, K., Kurita, Y., Hayashi, I., Masutani, M., Nakata, K., Tsuchiya, S., Isobe, H., Saijo, N. J. Clin. Oncol. (1999) [Pubmed]
  42. Epidemiology of primary hyperparathyroidism. Melton, L.J. J. Bone Miner. Res. (1991) [Pubmed]
  43. Acute and one year follow-up results after vessel size adapted PTCA using intracoronary ultrasound. Haase, K.K., Athanasiadis, A., Mahrholdt, H., Treusch, A., Wullen, B., Jaramillo, C., Baumbach, A., Voelker, W., Meisner, C., Karsch, K.R. Eur. Heart J. (1998) [Pubmed]
  44. Coronary artery bypass surgery vs coronary angioplasty: from antithesis to synthesis. Dimas, A.P., Healy, B. Eur. Heart J. (1989) [Pubmed]
  45. Vitamin E and heart disease: a case study. Kushi, L.H. Am. J. Clin. Nutr. (1999) [Pubmed]
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