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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Wichmann, O. et al.

Wichmann, Muehlen, Gruss, Mockenhaupt, Suttorp, Jelinek,

Malarone treatment failure not associated with previously described mutations in the cytochrome b gene.

Malarone (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are associated with mutations at codon 268 of the parasite's cytochrome b gene. We report the first case of Malarone treatment failure from Central Africa.Drug concentration was well within curative range. Pre- and post-treatment Plasmodium falciparum isolates revealed codon 268 wild-type alleles, and no other mutations of the putative atovaquone-binding domain.These findings illustrate the spread of atovaquone-proguanil-resistance in Africa and question the usefulness of codon 268 as the only target for the surveillance of its emergence.[1]

References

Malarone treatment failure not associated with previously described mutations in the cytochrome b gene. Wichmann, O., Muehlen, M., Gruss, H., Mockenhaupt, F.P., Suttorp, N., Jelinek, T. Malar. J. (2004) [Pubmed]

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