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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.

Intravenous treatment with Ag (peptide)-coupled, ethylene carbodiimide-fixed syngeneic splenocytes (Ag-SP) is a powerful method to induce anergy in vitro and peripheral T cell tolerance in vivo. In this study, we examined the effects of Ag-SP administration on T cell activity ex vivo and in vivo using OVA-specific DO11.10 TCR transgenic T cells. Although treatment with OVA323-339-SP resulted in a strong inhibition of peptide-specific T cell recall responses in vitro, examination of the immediate effects of Ag-SP treatment on T cells in vivo demonstrated that tolerogen injection resulted in rapid T cell activation and proliferation. Although there was an increase in the number of OVA-specific DO11.10 T cells detected in the lymphoid organs, these previously tolerized T cells were strongly inhibited in mounting proliferative or inflammatory responses upon rechallenge in vivo with peptide in CFA. This unresponsiveness was reversible by treatment with anti-CTLA-4 mAb. These results are consistent with the hypothesis that Ag-SP injection induces a state of T cell anergy that is maintained by CTLA-4 engagement.[1]

References

  1. CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance. Eagar, T.N., Turley, D.M., Padilla, J., Karandikar, N.J., Tan, L., Bluestone, J.A., Miller, S.D. J. Immunol. (2004) [Pubmed]
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