Gene Review:
Ctla4 - cytotoxic T-lymphocyte-associated protein 4
Mus musculus
Synonyms:
CTLA-4, Cd152, Ctla-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, ...
Kwon,
Foster,
Hurwitz,
Madias,
Allison,
Greenberg,
Burg,
Grohmann,
Orabona,
Fallarino,
Vacca,
Calcinaro,
Falorni,
Candeloro,
Belladonna,
Bianchi,
Fioretti,
Puccetti,
Brunkow,
Jeffery,
Hjerrild,
Paeper,
Clark,
Yasayko,
Wilkinson,
Galas,
Ziegler,
Ramsdell,
Mandelbrot,
McAdam,
Sharpe,
Ling,
Munroe,
Murphy,
Gray,
- An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Vijayakrishnan, L., Slavik, J.M., Illés, Z., Greenwald, R.J., Rainbow, D., Greve, B., Peterson, L.B., Hafler, D.A., Freeman, G.J., Sharpe, A.H., Wicker, L.S., Kuchroo, V.K. Immunity (2004)
- Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. Fife, B.T., Griffin, M.D., Abbas, A.K., Locksley, R.M., Bluestone, J.A. J. Clin. Invest. (2006)
- Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. LaBelle, J.L., Hanke, C.A., Blazar, B.R., Truitt, R.L. Blood (2002)
- Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis. Perrin, P.J., Scott, D., Quigley, L., Albert, P.S., Feder, O., Gray, G.S., Abe, R., June, C.H., Racke, M.K. J. Immunol. (1995)
- The amount of scurfin protein determines peripheral T cell number and responsiveness. Khattri, R., Kasprowicz, D., Cox, T., Mortrud, M., Appleby, M.W., Brunkow, M.E., Ziegler, S.F., Ramsdell, F. J. Immunol. (2001)
- Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen. Huang, T.H., Wu, P.Y., Lee, C.N., Huang, H.I., Hsieh, S.L., Kung, J., Tao, M.H. Blood (2000)
- Blockade of CTLA-4 signals inhibits Th2-mediated murine chronic graft-versus-host disease by an enhanced expansion of regulatory CD8+ T cells. Sakurai, J., Ohata, J., Saito, K., Miyajima, H., Hirano, T., Kohsaka, T., Enomoto, S., Okumura, K., Azuma, M. J. Immunol. (2000)
- Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Salomon, B., Bluestone, J.A. Annu. Rev. Immunol. (2001)
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow, M.E., Jeffery, E.W., Hjerrild, K.A., Paeper, B., Clark, L.B., Yasayko, S.A., Wilkinson, J.E., Galas, D., Ziegler, S.F., Ramsdell, F. Nat. Genet. (2001)
- Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Chen, L., Ashe, S., Brady, W.A., Hellström, I., Hellström, K.E., Ledbetter, J.A., McGowan, P., Linsley, P.S. Cell (1992)
- Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Ueda, H., Howson, J.M., Esposito, L., Heward, J., Snook, H., Chamberlain, G., Rainbow, D.B., Hunter, K.M., Smith, A.N., Di Genova, G., Herr, M.H., Dahlman, I., Payne, F., Smyth, D., Lowe, C., Twells, R.C., Howlett, S., Healy, B., Nutland, S., Rance, H.E., Everett, V., Smink, L.J., Lam, A.C., Cordell, H.J., Walker, N.M., Bordin, C., Hulme, J., Motzo, C., Cucca, F., Hess, J.F., Metzker, M.L., Rogers, J., Gregory, S., Allahabadia, A., Nithiyananthan, R., Tuomilehto-Wolf, E., Tuomilehto, J., Bingley, P., Gillespie, K.M., Undlien, D.E., Rønningen, K.S., Guja, C., Ionescu-Tîrgovişte, C., Savage, D.A., Maxwell, A.P., Carson, D.J., Patterson, C.C., Franklyn, J.A., Clayton, D.G., Peterson, L.B., Wicker, L.S., Todd, J.A., Gough, S.C. Nature (2003)
- Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Schwartz, J.C., Zhang, X., Fedorov, A.A., Nathenson, S.G., Almo, S.C. Nature (2001)
- The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. Eagar, T.N., Karandikar, N.J., Bluestone, J.A., Miller, S.D. Eur. J. Immunol. (2002)
- Effects of double blockade of CD28 and inducible-costimulator signaling on anti-glomerular basement membrane glomerulonephritis. Okano, K., Nitta, K., Ogawa, S., Horita, S., Habiro, K., Nihei, H., Abe, R. J. Lab. Clin. Med. (2004)
- Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy. Kwon, E.D., Foster, B.A., Hurwitz, A.A., Madias, C., Allison, J.P., Greenberg, N.M., Burg, M.B. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Prostate cancer: advances in immunotherapy. Hurwitz, A.A., Yanover, P., Markowitz, M., Allison, J.P., Kwon, E.D. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. (2003)
- Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. Wicker, L.S., Chamberlain, G., Hunter, K., Rainbow, D., Howlett, S., Tiffen, P., Clark, J., Gonzalez-Munoz, A., Cumiskey, A.M., Rosa, R.L., Howson, J.M., Smink, L.J., Kingsnorth, A., Lyons, P.A., Gregory, S., Rogers, J., Todd, J.A., Peterson, L.B. J. Immunol. (2004)
- Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene. Okabe, I., Nussbaum, R.L. Genomics (1995)
- Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Ostrov, D.A., Shi, W., Schwartz, J.C., Almo, S.C., Nathenson, S.G. Science (2000)
- Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Tivol, E.A., Borriello, F., Schweitzer, A.N., Lynch, W.P., Bluestone, J.A., Sharpe, A.H. Immunity (1995)
- Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells. Chen, W., Jin, W., Wahl, S.M. J. Exp. Med. (1998)
- Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice. Lamhamedi-Cherradi, S.E., Boulard, O., Gonzalez, C., Kassis, N., Damotte, D., Eloy, L., Fluteau, G., Lévi-Strauss, M., Garchon, H.J. Diabetes (2001)
- BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Watanabe, N., Gavrieli, M., Sedy, J.R., Yang, J., Fallarino, F., Loftin, S.K., Hurchla, M.A., Zimmerman, N., Sim, J., Zang, X., Murphy, T.L., Russell, J.H., Allison, J.P., Murphy, K.M. Nat. Immunol. (2003)
- CTLA-4-Ig regulates tryptophan catabolism in vivo. Grohmann, U., Orabona, C., Fallarino, F., Vacca, C., Calcinaro, F., Falorni, A., Candeloro, P., Belladonna, M.L., Bianchi, R., Fioretti, M.C., Puccetti, P. Nat. Immunol. (2002)
- Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. Tsuyuki, S., Tsuyuki, J., Einsle, K., Kopf, M., Coyle, A.J. J. Exp. Med. (1997)
- CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. Schneider, H., Valk, E., da Rocha Dias, S., Wei, B., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. Baroja, M.L., Vijayakrishnan, L., Bettelli, E., Darlington, P.J., Chau, T.A., Ling, V., Collins, M., Carreno, B.M., Madrenas, J., Kuchroo, V.K. J. Immunol. (2002)
- FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells. Daniel, C., Sartory, N., Zahn, N., Geisslinger, G., Radeke, H.H., Stein, J.M. J. Immunol. (2007)
- CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. Krummel, M.F., Allison, J.P. J. Exp. Med. (1996)
- DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice. Chang, Y., Yap, S., Ge, X., Piganelli, J., Bertera, S., Giannokakis, N., Mathews, C., Prud'homme, G., Trucco, M. Gene Ther. (2005)
- Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain. Guo, Y., Wu, Y., Zhao, M., Kong, X.P., Liu, Y. J. Exp. Med. (1995)
- Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance. Steurer, W., Nickerson, P.W., Steele, A.W., Steiger, J., Zheng, X.X., Strom, T.B. J. Immunol. (1995)
- Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition. Schneider, H., Rudd, C.E. Biochem. Biophys. Res. Commun. (2000)
- Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. Sugita, S., Streilein, J.W. J. Exp. Med. (2003)
- B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. Mandelbrot, D.A., Oosterwegel, M.A., Shimizu, K., Yamada, A., Freeman, G.J., Mitchell, R.N., Sayegh, M.H., Sharpe, A.H. J. Clin. Invest. (2001)
- CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. Krummel, M.F., Allison, J.P. J. Exp. Med. (1995)
- Unresponsive CD4+ T lymphocytes from Leishmania chagasi-infected mice increase cytokine production and mediate parasite killing after blockade of B7-1/CTLA-4 molecular pathway. Gomes, N.A., Barreto-de-Souza, V., Wilson, M.E., DosReis, G.A. J. Infect. Dis. (1998)
- B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Mandelbrot, D.A., McAdam, A.J., Sharpe, A.H. J. Exp. Med. (1999)
- B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge. Zheng, P., Wu, Y., Guo, Y., Lee, C., Liu, Y. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. Cong, Y., Konrad, A., Iqbal, N., Hatton, R.D., Weaver, C.T., Elson, C.O. J. Immunol. (2005)
- The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. Judge, T.A., Wu, Z., Zheng, X.G., Sharpe, A.H., Sayegh, M.H., Turka, L.A. J. Immunol. (1999)
- Embryonic stem cells and embryoid bodies express lymphocyte costimulatory molecules. Ling, V., Munroe, R.C., Murphy, E.A., Gray, G.S. Exp. Cell Res. (1998)
- B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice. Akiyama, Y., Shirasugi, N., Uchida, N., Matsumoto, K., Kitajima, M., Bashuda, H., Yagita, H., Okumura, K., Aramaki, O., Niimi, M. Transplantation (2002)