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Cytotoxic effect and electrophysiological study on human MRC-5 fibroblasts of R-irniine, a natural alkylpyrrolidine alkaloid.

R-irniine is a natural 2-alkylpyrrolidine alkaloid extracted from Arisarum vulgare Targ., a species belonging to the Araceae family known in Morocco for its toxicity. Cytotoxic and electrophysiological studies of this compound on human MRC-5 fibroblasts were carried out. Cytotoxic potential of R-irniine was detected on MRC-5 fibroblasts at 40 microg/mL. We carried out the electrophysiological study of this compound on MRC-5 cells by using the technique of patch-clamp in "Whole cell" configuration. R-irniine showed no effect on the outward potassium current of the MRC-5 fibroblasts.[1]

References

  1. Cytotoxic effect and electrophysiological study on human MRC-5 fibroblasts of R-irniine, a natural alkylpyrrolidine alkaloid. Lamkadem, M., Aziz, M., Schwob, I., Rabier, J., Mimouni, J., Fontonge, R., Melhaoui, A. Nat. Prod. Res. (2004) [Pubmed]
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