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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany.

An isolate of Streptococcus pyogenes isolated from a 63-year-old woman with a serious wound infection was found to be highly resistant to fluoroquinolones (levofloxacin MIC > or = 32 mg/L). DNA amplification and sequencing revealed a serine-81 to phenylalanine substitution in gyrA and three substitutions in parC: serine-79 to phenylalanine, aspartic acid-91 to asparagine, and serine-140 to proline. To our knowledge, this is the first report from a European country of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.[1]

References

  1. High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany. Reinert, R.R., Lütticken, R., Al-Lahham, A. Clin. Microbiol. Infect. (2004) [Pubmed]
 
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