Chemical Compound Review:
asparagine 2-amino-3-aminocarbonyl- propanoic acid
Synonyms:
asparagin, asparagina, Hasp, DL-Asparagine, DL-Aspartamine, ...
- Asparagine synthetase chemotherapy. Richards, N.G., Kilberg, M.S. Annu. Rev. Biochem. (2006)
- Abnormal lipid-linked oligosaccharides in class E Thy-1-negative mutant lymphomas. Trowbridge, I.S., Hyman, R. Cell (1979)
- Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Saada, A., Shaag, A., Mandel, H., Nevo, Y., Eriksson, S., Elpeleg, O. Nat. Genet. (2001)
- Processing of the asparagine-linked oligosaccharides of secreted and intracellular forms of the vesicular stomatitis virus G protein: in vivo evidence of Golgi apparatus compartmentalization. Gabel, C.A., Bergmann, J.E. J. Cell Biol. (1985)
- Processing of MOPC 315 immunoglobulin A oligosaccharides: evidence for endoplasmic reticulum and trans Golgi alpha 1,2-mannosidase activity. Hickman, S., Theodorakis, J.L., Greco, J.M., Brown, P.H. J. Cell Biol. (1984)
- Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511. Wetzler, M., Sanford, B.L., Kurtzberg, J., DeOliveira, D., Frankel, S.R., Powell, B.L., Kolitz, J.E., Bloomfield, C.D., Larson, R.A. Blood (2007)
- Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Kwon, Y.T., Balogh, S.A., Davydov, I.V., Kashina, A.S., Yoon, J.K., Xie, Y., Gaur, A., Hyde, L., Denenberg, V.H., Varshavsky, A. Mol. Cell. Biol. (2000)
- Hyperasparaginemia in a schizophrenic patient. Perry, T.L., Wright, J.M., Hansen, S. Biol. Psychiatry (1983)
- Free amino acids in the brain of patients with Parkinson's disease. Rinne, J.O., Halonen, T., Riekkinen, P.J., Rinne, U.K. Neurosci. Lett. (1988)
- Proline hydroxylation and gene expression. Kaelin, W.G. Annu. Rev. Biochem. (2005)
- A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion. DePace, A.H., Santoso, A., Hillner, P., Weissman, J.S. Cell (1998)
- Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Chui, D., Oh-Eda, M., Liao, Y.F., Panneerselvam, K., Lal, A., Marek, K.W., Freeze, H.H., Moremen, K.W., Fukuda, M.N., Marth, J.D. Cell (1997)
- Mutation of a type II keratin gene (K6a) in pachyonychia congenita. Bowden, P.E., Haley, J.L., Kansky, A., Rothnagel, J.A., Jones, D.O., Turner, R.J. Nat. Genet. (1995)
- Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein. Kelleher, D.J., Kreibich, G., Gilmore, R. Cell (1992)
- The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid. Berthet-Colominas, C., Seignovert, L., Härtlein, M., Grotli, M., Cusack, S., Leberman, R. EMBO J. (1998)
- Mutations in the coding region of c-MYC in AIDS-associated and other aggressive lymphomas. Clark, H.M., Yano, T., Otsuki, T., Jaffe, E.S., Shibata, D., Raffeld, M. Cancer Res. (1994)
- Role of Glutamine Depletion in Directing Tissue-specific Nutrient Stress Responses to L-Asparaginase. Reinert, R.B., Oberle, L.M., Wek, S.A., Bunpo, P., Wang, X.P., Mileva, I., Goodwin, L.O., Aldrich, C.J., Durden, D.L., McNurlan, M.A., Wek, R.C., Anthony, T.G. J. Biol. Chem. (2006)
- Site-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies. Guillaume, G., Vanhove, M., Lamotte-Brasseur, J., Ledent, P., Jamin, M., Joris, B., Frère, J.M. J. Biol. Chem. (1997)
- Purification and some properties of asparagine, lysine, serine, and valine:tRNA ligases from Bacillus stearothermophilus. Samuelsson, T., Lundvik, L. J. Biol. Chem. (1978)
- Selection of temperature-sensitive CHL asparagyl-tRNA synthetase mutants using the toxic lysine analog, S-2-aminoethyl-L-cysteine. Wasmuth, J.J., Caskey, C.T. Cell (1976)
- Mammalian cells with defective mitochondrial functions: a Chinese hamster mutant cell line lacking succinate dehydrogenase activity. Soderberg, K.L., Ditta, G.S., Scheffler, I.E. Cell (1977)
- Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum. Chin, D.J., Gil, G., Russell, D.W., Liscum, L., Luskey, K.L., Basu, S.K., Okayama, H., Berg, P., Goldstein, J.L., Brown, M.S. Nature (1984)
- Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation. Megee, P.C., Morgan, B.A., Mittman, B.A., Smith, M.M. Science (1990)
- FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Lando, D., Peet, D.J., Gorman, J.J., Whelan, D.A., Whitelaw, M.L., Bruick, R.K. Genes Dev. (2002)
- Transmembrane location of oligosaccharide-lipid synthesis in microsomal vesicles. Snider, M.D., Sultzman, L.A., Robbins, P.W. Cell (1980)
- CHO cells selected for phytohemagglutinin and con A resistance are defective in both early and late stages of protein glycosylation. Hunt, L.A. Cell (1980)
- TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences. Kanzaki, T., Olofsson, A., Morén, A., Wernstedt, C., Hellman, U., Miyazono, K., Claesson-Welsh, L., Heldin, C.H. Cell (1990)
- Amino-acid cycling drives nitrogen fixation in the legume-Rhizobium symbiosis. Lodwig, E.M., Hosie, A.H., Bourdès, A., Findlay, K., Allaway, D., Karunakaran, R., Downie, J.A., Poole, P.S. Nature (2003)
- Photoreceptor-specific degeneration caused by tunicamycin. Fliesler, S.J., Rapp, L.M., Hollyfield, J.G. Nature (1984)
- A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic 'tail' absent from purified glycoprotein. Boothroyd, J.C., Cross, G.A., Hoeijmakers, J.H., Borst, P. Nature (1980)
- A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors. Oksenberg, D., Marsters, S.A., O'Dowd, B.F., Jin, H., Havlik, S., Peroutka, S.J., Ashkenazi, A. Nature (1992)
- Acrylamide from Maillard reaction products. Stadler, R.H., Blank, I., Varga, N., Robert, F., Hau, J., Guy, P.A., Robert, M.C., Riediker, S. Nature (2002)
- Structure and function of human amphiregulin: a member of the epidermal growth factor family. Shoyab, M., Plowman, G.D., McDonald, V.L., Bradley, J.G., Todaro, G.J. Science (1989)
- Characterization of a gene controlling heterocyst differentiation in the cyanobacterium Anabaena 7120. Buikema, W.J., Haselkorn, R. Genes Dev. (1991)
- ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Ye, J., Rawson, R.B., Komuro, R., Chen, X., Davé, U.P., Prywes, R., Brown, M.S., Goldstein, J.L. Mol. Cell (2000)
- Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors. Dhalluin, C., Yan, K.S., Plotnikova, O., Lee, K.W., Zeng, L., Kuti, M., Mujtaba, S., Goldfarb, M.P., Zhou, M.M. Mol. Cell (2000)
- Isolation and sequence analysis of serine protease cDNAs from mouse cytolytic T lymphocytes. Kwon, B.S., Kestler, D., Lee, E., Wakulchik, M., Young, J.D. J. Exp. Med. (1988)
- OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides. Nakayama, K., Nagasu, T., Shimma, Y., Kuromitsu, J., Jigami, Y. EMBO J. (1992)
- Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution. Liu, K., Kozono, D., Kato, Y., Agre, P., Hazama, A., Yasui, M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis. Howell, E.E., Villafranca, J.E., Warren, M.S., Oatley, S.J., Kraut, J. Science (1986)
- Vascular expression of extracellular superoxide dismutase in atherosclerosis. Fukai, T., Galis, Z.S., Meng, X.P., Parthasarathy, S., Harrison, D.G. J. Clin. Invest. (1998)
- Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines. Kuner, T., Wollmuth, L.P., Karlin, A., Seeburg, P.H., Sakmann, B. Neuron (1996)
- Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA. Carman, W.F., Korula, J., Wallace, L., MacPhee, R., Mimms, L., Decker, R. Lancet (1995)
- Apolipoprotein B48 glycosylation in abetalipoproteinemia and Anderson's disease. Berriot-Varoqueaux, N., Dannoura, A.H., Moreau, A., Verthier, N., Sassolas, A., Cadiot, G., Lachaux, A., Munck, A., Schmitz, J., Aggerbeck, L.P., Samson-Bouma, M.E. Gastroenterology (2001)