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Chemical Compound Review

asparagine     2-amino-3-aminocarbonyl- propanoic acid

Synonyms: asparagin, asparagina, Hasp, DL-Asparagine, DL-Aspartamine, ...
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Disease relevance of asparagine


Psychiatry related information on asparagine


High impact information on asparagine


Chemical compound and disease context of asparagine


Biological context of asparagine


Anatomical context of asparagine

  • The oligosaccharide-lipid which is the precursor of asparagine-linked oligosaccharides of eucaryotic glycoproteins is synthesized from sugar nucleotides in the endoplasmic reticulum [25].
  • The lipid-linked and asparagine-linked oligosaccharides of two lectin-resistant and one parental Chinese hamster ovary (CHO) cell line have been compared by glycosidase digestion and gel filtration analysis of radiolabeled glycopeptides and oligosaccharides [26].
  • Most of the sequence of fibroblast TGF-beta 1-BP is made up of cysteine-rich repeats of two different kinds; there are 16 EGF-like repeats and three repeats with a distant resemblance to EGF, but of a distinct type hitherto not found in any other protein. beta-hydroxylated asparagine residues were identified in two of the EGF-like repeats [27].
  • In return, bacteroids act like plant organelles to cycle amino acids back to the plant for asparagine synthesis [28].
  • Rhodopsin, the visual pigment of retinal rod photoreceptor cells, is a membrane glycoprotein which consists of a single polypeptide chain (opsin) to which a chromophoric prosthetic group (II-cis-retinaldehyde) and two asparagine-linked oligosaccharide chains are covalently attached [29].

Associations of asparagine with other chemical compounds

  • Three of these VSGs terminated with a glycosylated aspartate or asparagine residue (Asx), suggesting that the VSG was cleaved following synthesis and glycosylation and before characterization [30].
  • Here we show that replacement of a single amino acid in the human receptor (threonine at residue 355) with a corresponding asparagine found in rodent 5-HT1B receptors renders the pharmacology of the receptors essentially identical [31].
  • Here we show that acrylamide can be released by the thermal treatment of certain amino acids (asparagine, for example), particularly in combination with reducing sugars, and of early Maillard reaction products (N-glycosides) [32].
  • The amino-terminal half of amphiregulin is extremely hydrophilic and contains unusually high numbers of lysine, arginine, and asparagine residues [33].
  • The mutation in 216 is located at nucleotide 535 in the hetR gene, converting a serine at position 179 in the wild-type protein to an asparagine in the mutant [34].

Gene context of asparagine


Analytical, diagnostic and therapeutic context of asparagine

  • One mutation, constructed by oligonucleotide-directed mutagenesis, replaces Asp27 with asparagine; the other is a primary-site revertant to Ser27 [40].
  • Sequence analysis revealed that this novel ecSOD has a 10-bp deletion in the 3' untranslated region and an asparagine to aspartic acid mutation at amino acid 21 [41].
  • A functionally critical asparagine (N-site) is positioned at the tip of the loop, and a cluster of hydrophilic residues of the descending limb, adjacent to the tip, forms the narrow constriction of the channel [42].
  • PCR sequencing revealed a substitution of arginine for glycine at position 145 of HBsAg in the major neutralising epitope cluster, the a determinant, as well as a 2-aminoacid insertion of asparagine and threonine between positions 122 and 123, immediately upstream of this determinant [43].
  • METHODS: Asparagine-linked oligosaccharide processing of apolipoprotein B48 in normal and affected individuals was determined by the endoglycosidase H and F sensitivities of the protein after metabolic labeling of intestinal explants in organ culture [44].


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  15. The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid. Berthet-Colominas, C., Seignovert, L., Härtlein, M., Grotli, M., Cusack, S., Leberman, R. EMBO J. (1998) [Pubmed]
  16. Mutations in the coding region of c-MYC in AIDS-associated and other aggressive lymphomas. Clark, H.M., Yano, T., Otsuki, T., Jaffe, E.S., Shibata, D., Raffeld, M. Cancer Res. (1994) [Pubmed]
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  18. Site-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies. Guillaume, G., Vanhove, M., Lamotte-Brasseur, J., Ledent, P., Jamin, M., Joris, B., Frère, J.M. J. Biol. Chem. (1997) [Pubmed]
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  20. Selection of temperature-sensitive CHL asparagyl-tRNA synthetase mutants using the toxic lysine analog, S-2-aminoethyl-L-cysteine. Wasmuth, J.J., Caskey, C.T. Cell (1976) [Pubmed]
  21. Mammalian cells with defective mitochondrial functions: a Chinese hamster mutant cell line lacking succinate dehydrogenase activity. Soderberg, K.L., Ditta, G.S., Scheffler, I.E. Cell (1977) [Pubmed]
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  24. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Lando, D., Peet, D.J., Gorman, J.J., Whelan, D.A., Whitelaw, M.L., Bruick, R.K. Genes Dev. (2002) [Pubmed]
  25. Transmembrane location of oligosaccharide-lipid synthesis in microsomal vesicles. Snider, M.D., Sultzman, L.A., Robbins, P.W. Cell (1980) [Pubmed]
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