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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A case of hepatocellular carcinoma with situs inversus totalis.

We report a case of hepatocellular carcinoma with situs inversus totalis treated by hepatectomy. A 70-year-old asymptomatic female with hepatocellular carcinomas in segments 5, 6 and 8 underwent transarterial embolization in the department of medicine. However, hepatocellular carcinoma in segment 8 relapsed, and she was referred to the department of surgery. Laboratory tests revealed elevation of serum PIVKA2 level (4,690 ng/mL). Angiography revealed tumor stain in segment 8, 3 cm in diameter. No aberrant vessels were detected on angiography. The operator stood on the patient's left, and partial hepatectomy could be performed safety after careful examination of the anatomy. Although aberrant vessels are detected in many patients with situs inversus totalis, operations can be performed safely on them with sufficient understanding of the anatomy.[1]


  1. A case of hepatocellular carcinoma with situs inversus totalis. Kakinuma, D., Tajiri, T., Yoshida, H., Mamada, Y., Taniai, N., Kawano, Y., Mizuguchi, Y., Shimizu, T., Takahashi, T., Akimaru, K., Aramaki, T., Takano, T. Journal of Nippon Medical School = Nihon Ika Daigaku zasshi. (2004) [Pubmed]
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