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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Situs Inversus

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Disease relevance of Situs Inversus


High impact information on Situs Inversus


Chemical compound and disease context of Situs Inversus


Biological context of Situs Inversus


Anatomical context of Situs Inversus


Gene context of Situs Inversus

  • Finally, this study demonstrates a link between ciliary function and situs determination, since compound mutation heterozygosity in DNAI1 results in PCD with situs solitus or situs inversus (KS) [8].
  • Infantile nephronophthisis is associated with cystic kidneys, situs inversus, and INVS mutations [20].
  • Here we identify the conserved type ID unconventional myosin 31DF gene (Myo31DF) as a unique situs inversus locus in Drosophila [21].
  • These results indicate that alpha 1 adrenergic stimulation-induced situs inversus is mediated by the alpha 1A adrenergic receptor subtype and that activation of CaM kinase II but not PKC may be involved [11].
  • We have investigated the expression of left/right (L/R) asymmetry markers, nodal and lefty, in the situs inversus mouse mutant Fused toes (Ft) [22].

Analytical, diagnostic and therapeutic context of Situs Inversus


  1. Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia. Bartoloni, L., Blouin, J.L., Pan, Y., Gehrig, C., Maiti, A.K., Scamuffa, N., Rossier, C., Jorissen, M., Armengot, M., Meeks, M., Mitchison, H.M., Chung, E.M., Delozier-Blanchet, C.D., Craigen, W.J., Antonarakis, S.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome. Kobayashi, Y., Watanabe, M., Okada, Y., Sawa, H., Takai, H., Nakanishi, M., Kawase, Y., Suzuki, H., Nagashima, K., Ikeda, K., Motoyama, N. Mol. Cell. Biol. (2002) [Pubmed]
  3. Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus. Ibañez-Tallon, I., Gorokhova, S., Heintz, N. Hum. Mol. Genet. (2002) [Pubmed]
  4. Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Kramer-Zucker, A.G., Olale, F., Haycraft, C.J., Yoder, B.K., Schier, A.F., Drummond, I.A. Development (2005) [Pubmed]
  5. Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Otto, E.A., Schermer, B., Obara, T., O'Toole, J.F., Hiller, K.S., Mueller, A.M., Ruf, R.G., Hoefele, J., Beekmann, F., Landau, D., Foreman, J.W., Goodship, J.A., Strachan, T., Kispert, A., Wolf, M.T., Gagnadoux, M.F., Nivet, H., Antignac, C., Walz, G., Drummond, I.A., Benzing, T., Hildebrandt, F. Nat. Genet. (2003) [Pubmed]
  6. X-linked situs abnormalities result from mutations in ZIC3. Gebbia, M., Ferrero, G.B., Pilia, G., Bassi, M.T., Aylsworth, A., Penman-Splitt, M., Bird, L.M., Bamforth, J.S., Burn, J., Schlessinger, D., Nelson, D.L., Casey, B. Nat. Genet. (1997) [Pubmed]
  7. Cloning of inv, a gene that controls left/right asymmetry and kidney development. Mochizuki, T., Saijoh, Y., Tsuchiya, K., Shirayoshi, Y., Takai, S., Taya, C., Yonekawa, H., Yamada, K., Nihei, H., Nakatsuji, N., Overbeek, P.A., Hamada, H., Yokoyama, T. Nature (1998) [Pubmed]
  8. Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome). Guichard, C., Harricane, M.C., Lafitte, J.J., Godard, P., Zaegel, M., Tack, V., Lalau, G., Bouvagnet, P. Am. J. Hum. Genet. (2001) [Pubmed]
  9. Evidence for an adrenergic mechanism in the control of body asymmetry. Fujinaga, M., Baden, J.M. Dev. Biol. (1991) [Pubmed]
  10. Retinoic acid directs cardiac laterality and the expression of early markers of precardiac asymmetry. Smith, S.M., Dickman, E.D., Thompson, R.P., Sinning, A.R., Wunsch, A.M., Markwald, R.R. Dev. Biol. (1997) [Pubmed]
  11. Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos. Fujinaga, M., Hoffman, B.B., Baden, J.M. Dev. Biol. (1994) [Pubmed]
  12. Activation of alpha-1 adrenergic receptors modulates the control of left/right sidedness in rat embryos. Fujinaga, M., Maze, M., Hoffman, B.B., Baden, J.M. Dev. Biol. (1992) [Pubmed]
  13. Congenital heart disease in patients with Down's syndrome: anatomic and genetic aspects. Marino, B. Biomed. Pharmacother. (1993) [Pubmed]
  14. Linkage analysis localises a Kartagener syndrome gene to a 3.5 cM region on chromosome 15q24-25. Geremek, M., Zietkiewicz, E., Diehl, S.R., Alizadeh, B.Z., Wijmenga, C., Witt, M. J. Med. Genet. (2006) [Pubmed]
  15. Anomalous systemic venous return: recognition by two-dimensional echocardiography. Foale, R., Bourdillon, P.D., Somerville, J., Rickards, A. Eur. Heart J. (1983) [Pubmed]
  16. Correlation of forelimb malformation asymmetries with visceral organ situs in the transgenic mouse insertional mutation, legless. Schreiner, C.M., Scott, W.J., Supp, D.M., Potter, S.S. Dev. Biol. (1993) [Pubmed]
  17. Left preureteral vena cava (retrocaval or circumcaval ureter) associated with partial situs inversus. Watanabe, M., Kawamura, S., Nakada, T., Ishii, N., Hirano, K., Numasawa, K., Imamura, A. J. Urol. (1991) [Pubmed]
  18. Situs inversus, subaortic and subpulmonic stenosis, ventricular septal defect, and single coronary artery. Kleinfeld, M., Rozanski, J.J., Brumlik, J.V. Chest (1976) [Pubmed]
  19. MRI of polysplenia syndrome. Jelinek, J.S., Stuart, P.L., Done, S.L., Ghaed, N., Rudd, S.A. Magnetic resonance imaging. (1989) [Pubmed]
  20. Analysis of multiple Invs transcripts in mouse and MDCK cells. Ward, H.H., Wang, J., Phillips, C. Genomics (2004) [Pubmed]
  21. Type ID unconventional myosin controls left-right asymmetry in Drosophila. Spéder, P., Adám, G., Noselli, S. Nature (2006) [Pubmed]
  22. The expression pattern of nodal and lefty in the mouse mutant Ft suggests a function in the establishment of handedness. Heymer, J., Kuehn, M., Rüther, U. Mech. Dev. (1997) [Pubmed]
  23. Right varicocele associated with inferior vena cava malformation in situs inversus: percutaneous treatment with retrograde sclerotherapy. Preziosi, P., Miano, R., Bitelli, M., Ciolfi, M.G., Micali, S., Micali, F. J. Endourol. (2001) [Pubmed]
  24. Radiofrequency catheter ablation of a coronary sinus-ventricular accessory connection in dextrocardia with complete situs inversus and an anomalous inferior vena cava. Taniguchi, H., Miyauchi, Y., Kobayashi, Y., Hirasawa, Y., Hosaka, H., Iwasaki, Y.K., Katoh, T., Takano, T. Pacing and clinical electrophysiology : PACE. (2005) [Pubmed]
  25. A case of hepatocellular carcinoma with situs inversus totalis. Kakinuma, D., Tajiri, T., Yoshida, H., Mamada, Y., Taniai, N., Kawano, Y., Mizuguchi, Y., Shimizu, T., Takahashi, T., Akimaru, K., Aramaki, T., Takano, T. Journal of Nippon Medical School = Nihon Ika Daigaku zasshi. (2004) [Pubmed]
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