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Enantioseparation of tiropramide by HPLC.

Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.[1]


  1. Enantioseparation of tiropramide by HPLC. Ryoo, J.J., Heo, K.S., Choi, E.S., Park, J.H., Lee, W. Chirality. (2004) [Pubmed]
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