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Chemical Compound Review

Tirospan     N-[2-[4-(2- diethylaminoethoxy)phenyl]- 1...

Synonyms: Maiorad, Maioral, Tiropramida, Tiropramide, Tiropramidum, ...
 
 
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Disease relevance of CR-605

 

Psychiatry related information on CR-605

 

High impact information on CR-605

  • A simple sample preparation with HPLC-UV method for estimation of tiropramide from plasma: Application to bioequivalence study [3].
  • An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases [4].
  • When tiropramide was added during the sustained phase of the K+ (60 mM)-contracture, IC50 values of tiropramide for the contraction and the increased fluorescence were 1.9 x 10(-5) M and 16.4 x 10(-5) M, respectively [5].
  • Mechanism of smooth muscle relaxation by tiropramide [6].
  • Tiropramide inhibited phosphodiesterase activity in rabbit colon homogenates in a range of doses about ten times that producing relaxation, cAMP content enhancement and increase Ca2+ binding to sarcoplasmic reticulum [6].
 

Chemical compound and disease context of CR-605

 

Biological context of CR-605

 

Anatomical context of CR-605

 

Associations of CR-605 with other chemical compounds

 

Gene context of CR-605

 

Analytical, diagnostic and therapeutic context of CR-605

  • A sensitive, selective and simple gas chromatography coupled to mass spectrometry (GC/MS) was developed for quantification of tiropramide in human plasma using internal standard (ISD, (+/-) alpha-benzoylamino-4-[2-(dimethylamino) ethoxy]-N,N-dipropylbenzenepropanamide) [12].
  • Enantioseparation of tiropramide by HPLC [4].
  • A rapid and sensitive column-switching semi-micro high-performance liquid chromatography method was developed for the direct analysis of tiropramide in human plasma [13].
  • Plasma samples obtained from human volunteers were analyzed for the determination of tiropramide concentration by using this method [10].
  • Two kinds of tiropramide tablets were orally administered to volunteers by Latin square crossover design, and blood was withdrawn as designed schedule [10].

References

  1. Controlled study of the effects of tiropramide on biliary dyskinesia. Trabucchi, E., Baratti, C., Centemero, A., Zuin, M., Rizzitelli, E., Colombo, R. Pharmatherapeutica. (1986) [Pubmed]
  2. Antispasmodic activity of tiropramide. Setnikar, I., Cereda, R., Pacini, M.A., Revel, L., Makovec, F. Arzneimittel-Forschung. (1989) [Pubmed]
  3. A simple sample preparation with HPLC-UV method for estimation of tiropramide from plasma: Application to bioequivalence study. Imran, K., Punnamchand, L., Natvarlal, S.M. Journal of pharmaceutical and biomedical analysis (2007) [Pubmed]
  4. Enantioseparation of tiropramide by HPLC. Ryoo, J.J., Heo, K.S., Choi, E.S., Park, J.H., Lee, W. Chirality. (2004) [Pubmed]
  5. Possible mechanisms of action of the antispasmodic agent tiropramide in the isolated detrusor from rats. Uruno, T., Shirane, M., Wada, K., Tsunematsu, R., Nagahamaya, K., Matsuoka, Y., Sunagane, N., Kubota, K. Jpn. J. Pharmacol. (1992) [Pubmed]
  6. Mechanism of smooth muscle relaxation by tiropramide. Vidal y Plana, R.R., Cifarelli, A., Setnikar, I. J. Pharm. Pharmacol. (1981) [Pubmed]
  7. Pharmacokinetics of tiropramide after single doses in man. Arigoni, R., Chisté, R., Drovanti, A., Makovec, F., Senin, P., Setnikar, I. Arzneimittel-Forschung. (1986) [Pubmed]
  8. Tiropramide and metabolites in blood and plasma after intravenous or peroral administration of 14C-tiropramide to the rat. Setnikar, I., Makovec, F., Chistè, R., Giachetti, C., Zanolo, G. Arzneimittel-Forschung. (1988) [Pubmed]
  9. Pharmacological characterisation of the smooth muscle antispasmodic agent tiropramide. Setnikar, I., Cereda, R., Pacini, M.A., Revel, L., Makovec, F. Arzneimittel-Forschung. (1989) [Pubmed]
  10. Quantitative analysis of tiropramide in human blood by gas chromatography with nitrogen-phosphorus detector. Kwon, O.S., Park, Y.J., Ryu, J.C., Chung, Y.B. Arch. Pharm. Res. (2003) [Pubmed]
  11. Pharmacokinetics and bioequivalence of tiropramide in healthy volunteers. Kwon, O.S., Park, Y.J., Chung, Y.B. Arzneimittel-Forschung. (2003) [Pubmed]
  12. Quantitative analysis of tiropramide in human plasma by gas chromatography coupled to mass spectrometry for application to a bioequivalence test. Jhee, O.H., Jeon, Y.C., Choi, H.S., Lee, M.H., Om, A.S., Lee, J.W., Hong, J.W., Kim, Y.S., Kang, J.C., Lee, Y.S., Shaw, L.M., Kang, J.S. Clin. Chim. Acta (2006) [Pubmed]
  13. Semi-micro high-performance liquid chromatographic analysis of tiropramide in human plasma using column-switching. Baek, S.K., Lee, S.S., Park, E.J., Sohn, D.H., Lee, H.S. Journal of pharmaceutical and biomedical analysis. (2003) [Pubmed]
 
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