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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.

Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.[1]

References

  1. MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity. Morerio, C., Rapella, A., Rosanda, C., Lanino, E., Lo Nigro, L., Di Cataldo, A., Maserati, E., Pasquali, F., Panarello, C. Cancer Genet. Cytogenet. (2004) [Pubmed]
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