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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Tolerance of normal human brain to boron neutron capture therapy.

Data from the Harvard-MIT and the BNL Phase I and Phase I/II clinical trials, conducted between 1994 and 1999, have been analyzed and combined, providing the most complete data set yet available on the tolerance of the normal human brain to BPA-mediated boron neutron capture therapy. Both peak (1cm(3)) dose and average whole-brain dose show a steep dose-response relationship using somnolence syndrome as the clinical endpoint. Probit analysis indicates that the doses associated with a 50% incidence for somnolence (ED(50)+/-SE) were 6.2+/-1.0 Gy(w) for average whole-brain dose and 14.1+/-1.8 Gy(w) for peak brain dose.[1]


  1. Tolerance of normal human brain to boron neutron capture therapy. Coderre, J.A., Hopewell, J.W., Turcotte, J.C., Riley, K.J., Binns, P.J., Kiger, W.S., Harling, O.K. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2004) [Pubmed]
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