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MeSH Review

Boron Neutron Capture Therapy

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Disease relevance of Boron Neutron Capture Therapy


High impact information on Boron Neutron Capture Therapy

  • The viability of boron neutron capture therapy depends on the development of tumor-targeting agents that contain large numbers of boron-10 (10B) atoms and are readily taken up by cells [6].
  • 7. The boron concentration obtained in the tumor corresponds to 22.2% injected dose (i.d.) per g of tissue, a value analogous to the most promising polyhedral borane anions investigated for liposomal delivery and subsequent application in boron neutron capture therapy [7].
  • The sodium salts of both the ae and the a2 isomers of [B20H17NH3]3- have been encapsulated within small unilamellar liposomes, composed of distearoyl phosphatidylcholine/cholesterol (1:1), and investigated as boron-delivery agents for boron neutron capture therapy (BNCT) of cancer [8].
  • Evaluation of human thymidine kinase 1 substrates as new candidates for boron neutron capture therapy [9].
  • Since these methyl thioethers can be prepared easily in B-10-enriched form on a large scale and due to their chemical versatility, they are potentially very attractive boron entities for the design and synthesis of therapeutics for boron neutron capture therapy of cancer [10].

Chemical compound and disease context of Boron Neutron Capture Therapy


Biological context of Boron Neutron Capture Therapy


Anatomical context of Boron Neutron Capture Therapy


Associations of Boron Neutron Capture Therapy with chemical compounds


Gene context of Boron Neutron Capture Therapy


Analytical, diagnostic and therapeutic context of Boron Neutron Capture Therapy


  1. Model studies directed toward the application of boron neutron capture therapy to rheumatoid arthritis: boron delivery by liposomes in rat collagen-induced arthritis. Watson-Clark, R.A., Banquerigo, M.L., Shelly, K., Hawthorne, M.F., Brahn, E. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Accumulation of 10B in the central degenerative areas of human glioma and colon carcinoma spheroids after sulfhydryl boron hydride administration. Pettersson, O.A., Carlsson, J., Grusell, E. Cancer Res. (1992) [Pubmed]
  3. Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene. Morita, N., Hiratsuka, J., Kondoh, H., Uno, M., Asano, T., Niki, Y., Sakurai, Y., Ono, K., Harada, T., Imajo, Y. Cancer Res. (2006) [Pubmed]
  4. Treatment of isografted 9L rat brain tumors with beta-5-o-carboranyl-2'-deoxyuridine neutron capture therapy. Schinazi, R.F., Hurwitz, S.J., Liberman, I., Juodawlkis, A.S., Tharnish, P., Shi, J., Liotta, D.C., Coderre, J.A., Olson, J. Clin. Cancer Res. (2000) [Pubmed]
  5. Boronated protoporphyrin (BOPP): localization in lysosomes of the human glioma cell line SF-767 with uptake modulated by lipoprotein levels. Callahan, D.E., Forte, T.M., Afzal, S.M., Deen, D.F., Kahl, S.B., Bjornstad, K.A., Bauer, W.F., Blakely, E.A. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  6. Toward a cancer therapy with boron-rich oligomeric phosphate diesters that target the cell nucleus. Nakanishi, A., Guan, L., Kane, R.R., Kasamatsu, H., Hawthorne, M.F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Synthesis and in vivo murine evaluation of Na4[1-(1'-B10H9)-6-SHB10H8] as a potential agent for boron neutron capture therapy. Feakes, D.A., Waller, R.C., Hathaway, D.K., Morton, V.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. Na3[B20H17NH3]: synthesis and liposomal delivery to murine tumors. Feakes, D.A., Shelly, K., Knobler, C.B., Hawthorne, M.F. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  9. Evaluation of human thymidine kinase 1 substrates as new candidates for boron neutron capture therapy. Al-Madhoun, A.S., Johnsamuel, J., Barth, R.F., Tjarks, W., Eriksson, S. Cancer Res. (2004) [Pubmed]
  10. S-alkylation and S-amination of methyl thioethers--derivatives of closo-[B(12)H(12)](2-). synthesis of a boronated phosphonate, gem-bisphosphonates, and dodecaborane-ortho-carborane oligomers. Kultyshev, R.G., Liu, J., Liu, S., Tjarks, W., Soloway, A.H., Shore, S.G. J. Am. Chem. Soc. (2002) [Pubmed]
  11. Synthesis of boroxifen, a nido-carborane analogue of tamoxifen. Valliant, J.F., Schaffer, P., Stephenson, K.A., Britten, J.F. J. Org. Chem. (2002) [Pubmed]
  12. Enhanced delivery of boronophenylalanine for neutron capture therapy of brain tumors using the bradykinin analog Cereport (Receptor-Mediated Permeabilizer-7). Barth, R.F., Yang, W., Bartus, R.T., Moeschberger, M.L., Goodman, J.H. Neurosurgery (1999) [Pubmed]
  13. Improved treatment planning for boron neutron capture therapy for glioblastoma multiforme using fluorine-18 labeled boronophenylalanine and positron emission tomography. Nichols, T.L., Kabalka, G.W., Miller, L.F., Khan, M.K., Smith, G.T. Medical physics. (2002) [Pubmed]
  14. Targeting normal and neoplastic tissues in the rat jejunum and colon with boronated, cationic acrylamide copolymers. Azab, A.K., Srebnik, M., Doviner, V., Rubinstein, A. Journal of controlled release : official journal of the Controlled Release Society. (2005) [Pubmed]
  15. Biodistribution of boron concentration on melanoma-bearing hamsters after administration of p-, m-, o-boronophenylalanine. Hiratsuka, J., Yoshino, K., Kondoh, H., Imajo, Y., Mishima, Y. Jpn. J. Cancer Res. (2000) [Pubmed]
  16. Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model. Yanagië, H., Tomita, T., Kobayashi, H., Fujii, Y., Takahashi, T., Hasumi, K., Nariuchi, H., Sekiguchi, M. Br. J. Cancer (1991) [Pubmed]
  17. Cell survival measurements in an argon, aluminium and sulphur filtered neutron beam: a comparison with 24 keV neutrons and relevance to boron neutron capture therapy. Mill, A.J., Morgan, G.R., Newman, S.M. The British journal of radiology. (1994) [Pubmed]
  18. In vitro induction of chromosomal aberrations in human lymphocytes, with and without boron 10, by radiations concerned in boron neutron capture therapy. Lloyd, D.C., Edwards, A.A., Prosser, J.S., Finnon, P., Moquet, J.E. The British journal of radiology. (1988) [Pubmed]
  19. Model studies directed toward the boron neutron-capture therapy of cancer: boron delivery to murine tumors with liposomes. Shelly, K., Feakes, D.A., Hawthorne, M.F., Schmidt, P.G., Krisch, T.A., Bauer, W.F. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  20. Imaging of fluorine and boron from fluorinated boronophenylalanine in the same cell at organelle resolution by correlative ion microscopy and confocal laser scanning microscopy. Chandra, S., Kabalka, G.W., Lorey, D.R., Smith, D.R., Coderre, J.A. Clin. Cancer Res. (2002) [Pubmed]
  21. Synthesis and in vitro evaluation of boronated uridine and glucose derivatives for boron neutron capture therapy. Tjarks, W., Anisuzzaman, A.K., Liu, L., Soloway, A.H., Barth, R.F., Perkins, D.J., Adams, D.M. J. Med. Chem. (1992) [Pubmed]
  22. Relaxation properties of a dual-labeled probe for MRI and neutron capture therapy. Tatham, A.T., Nakamura, H., Wiener, E.C., Yamamoto, Y. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1999) [Pubmed]
  23. The combined effect of boronophenylalanine and borocaptate in boron neutron capture therapy for SCCVII tumors in mice. Ono, K., Masunaga, S., Suzuki, M., Kinashi, Y., Takagaki, M., Akaboshi, M. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  24. Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors. Winum, J.Y., Cecchi, A., Montero, J.L., Innocenti, A., Scozzafava, A., Supuran, C.T. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  25. Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma. Tsuboi, T., Kondoh, H., Hiratsuka, J., Mishima, Y. Pigment Cell Res. (1998) [Pubmed]
  26. Strategy for boron neutron capture therapy against tumor cells with over-expression of the epidermal growth factor-receptor. Carlsson, J., Gedda, L., Grönvik, C., Hartman, T., Lindström, A., Lindström, P., Lundqvist, H., Lövqvist, A., Malmqvist, J., Olsson, P. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  27. Toxicity, biodistribution, and convection-enhanced delivery of the boronated porphyrin BOPP in the 9L intracerebral rat glioma model. Ozawa, T., Afzal, J., Lamborn, K.R., Bollen, A.W., Bauer, W.F., Koo, M.S., Kahl, S.B., Deen, D.F. Int. J. Radiat. Oncol. Biol. Phys. (2005) [Pubmed]
  28. Inborn errors in metabolism and 4-boronophenylalanine-fructose-based boron neutron capture therapy. Laakso, J., Ruokonen, I., Lapatto, R., Kallio, M. Radiat. Res. (2003) [Pubmed]
  29. Analysis of boron-10 in soft tissue by dynamic secondary ion mass spectrometry. Oyedepo, A.C., Brooke, S.L., Heard, P.J., Day, J.C., Allen, G.C., Patel, H. Journal of microscopy. (2004) [Pubmed]
  30. Tolerance of normal human brain to boron neutron capture therapy. Coderre, J.A., Hopewell, J.W., Turcotte, J.C., Riley, K.J., Binns, P.J., Kiger, W.S., Harling, O.K. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2004) [Pubmed]
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