The G-netics of dark skin.
Several mutant strains of mice have dark skin pigmentation due to an aberrant accumulation of pigment-producing melanocytes in the dermal layer of the skin. A new study shows that three such strains carry activating mutations in the genes encoding the G-protein subunits Galphaq or Galpha11, resulting in more pigment cell precursors and an excess of dermally retained pigment cells at birth.[1]References
- The G-netics of dark skin. Jackson, I.J. Nat. Genet. (2004) [Pubmed]
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