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MeSH Review

Mice, Mutant Strains

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Disease relevance of Mice, Mutant Strains


Psychiatry related information on Mice, Mutant Strains

  • The serologic lesion of the I-A mutant mouse strain, bm12, was investigated with the use of monoclonal anti-Iab antibodies and anti-idiotypic (Id) reagents produced against these antibodies [4].

High impact information on Mice, Mutant Strains


Biological context of Mice, Mutant Strains


Anatomical context of Mice, Mutant Strains


Associations of Mice, Mutant Strains with chemical compounds


Gene context of Mice, Mutant Strains

  • The role of these interactions under physiological conditions was investigated using a mutant mouse strain that expresses a truncated Cabin1 lacking the COOH-terminal calcineurin and MEF2 binding domains [25].
  • Here we use mutant mouse strains to investigate the function of E2F1 and E2F2 in vivo [26].
  • This indicates that combined deficiencies of LPL and hepatic lipase, observed in humans as well as in certain mutant strains of mice, do not result from focal disruptions of a cluster of lipase genes [27].
  • TLR4 normal or mutant mouse strain was compared to investigate the possible role of TLR4 in acute HBV expression [28].
  • The neuroprotective effects of CNTF have been demonstrated in a number of in vitro cell models as well as in vivo in mutant mouse strains which exhibit motor neuron degeneration [29].

Analytical, diagnostic and therapeutic context of Mice, Mutant Strains


  1. A murine model for type III tyrosinemia: lack of immunologically detectable 4-hydroxyphenylpyruvic acid dioxygenase enzyme protein in a novel mouse strain with hypertyrosinemia. Endo, F., Katoh, H., Yamamoto, S., Matsuda, I. Am. J. Hum. Genet. (1991) [Pubmed]
  2. Traumatic brain injury causes delayed motor and cognitive impairment in a mutant mouse strain known to exhibit delayed Wallerian degeneration. Fox, G.B., Faden, A.I. J. Neurosci. Res. (1998) [Pubmed]
  3. Altered cell proliferation in the spinal cord of mouse neural tube mutants curly tail and Pax3 splotch-delayed. Keller-Peck, C.R., Mullen, R.J. Brain Res. Dev. Brain Res. (1997) [Pubmed]
  4. Idiotypic and fluorometric analysis of the antibodies that distinguish the lesion of the I-A mutant B6.C-H-2bm12. Melino, M.R., Epstein, S.L., Sachs, D.H., Hansen, T.H. J. Immunol. (1983) [Pubmed]
  5. CD8 is needed for development of cytotoxic T cells but not helper T cells. Fung-Leung, W.P., Schilham, M.W., Rahemtulla, A., Kündig, T.M., Vollenweider, M., Potter, J., van Ewijk, W., Mak, T.W. Cell (1991) [Pubmed]
  6. Abolition of specific immune response defect by immunization with dendritic cells. Boog, C.J., Kast, W.M., Timmers, H.T., Boes, J., de Waal, L.P., Melief, C.J. Nature (1985) [Pubmed]
  7. An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Tepper, R.I., Coffman, R.L., Leder, P. Science (1992) [Pubmed]
  8. E2f3 is critical for normal cellular proliferation. Humbert, P.O., Verona, R., Trimarchi, J.M., Rogers, C., Dandapani, S., Lees, J.A. Genes Dev. (2000) [Pubmed]
  9. Mice with a fluorescent marker for interleukin 2 gene activation. Naramura, M., Hu, R.J., Gu, H. Immunity (1998) [Pubmed]
  10. The glomerulosclerosis gene Mpv17 encodes a peroxisomal protein producing reactive oxygen species. Zwacka, R.M., Reuter, A., Pfaff, E., Moll, J., Gorgas, K., Karasawa, M., Weiher, H. EMBO J. (1994) [Pubmed]
  11. Expression of the proopiomelanocortin gene is developmentally regulated and affected by germ cells in the male mouse reproductive system. Gizang-Ginsberg, E., Wolgemuth, D.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  12. Ia specificities on parental and hybrid cells of an I-A mutant mouse strain. Hansen, T.H., Walsh, W.D., Ozato, K., Arn, J.S., Sachs, D.H. J. Immunol. (1981) [Pubmed]
  13. Developmentally regulated transcription of the four liver-specific genes for inter-alpha-inhibitor family in mouse. Salier, J.P., Chan, P., Raguenez, G., Zwingman, T., Erickson, R.P. Biochem. J. (1993) [Pubmed]
  14. Human homologue of a gene mutated in the slow Wallerian degeneration (C57BL/Wld(s)) mouse. Fernando, F.S., Conforti, L., Tosi, S., Smith, A.D., Coleman, M.P. Gene (2002) [Pubmed]
  15. T cell responses to select Ia determinants using the I-A mutant mouse strain B6.C-H-2bm12. Skelly, R.R., Pappas, F., Koprak, S., Ahmed, A., Hansen, T.H. J. Immunol. (1982) [Pubmed]
  16. The tissue-specific expression of lipoprotein lipase: implications for energy and lipoprotein metabolism. Zechner, R. Curr. Opin. Lipidol. (1997) [Pubmed]
  17. A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains. Kennedy, B.P., Payette, P., Mudgett, J., Vadas, P., Pruzanski, W., Kwan, M., Tang, C., Rancourt, D.E., Cromlish, W.A. J. Biol. Chem. (1995) [Pubmed]
  18. Increased mitochondrial respiratory chain enzyme activities correlate with minor extent of liver damage in mice suffering from erythropoietic protoporphyria. Navarro, S., Del Hoyo, P., Campos, Y., Abitbol, M., Morán-Jiménez, M.J., García-Bravo, M., Ochoa, P., Grau, M., Montagutelli, X., Frank, J., Garesse, R., Arenas, J., de Salamanca, R.E., Fontanellas, A. Exp. Dermatol. (2005) [Pubmed]
  19. Endocrine-dependent regulation of tetrahydrobiopterin levels and guanosine triphosphate cyclohydrolase activity. Duch, D.S., Bowers, S.W., Nichol, C.A. Mol. Cell. Endocrinol. (1986) [Pubmed]
  20. Regulation of iron absorption in Hfe mutant mice. Ajioka, R.S., Levy, J.E., Andrews, N.C., Kushner, J.P. Blood (2002) [Pubmed]
  21. Enhanced sodium-dependent extrusion of magnesium in mutant cells established from a mouse renal tubular cell line. Watanabe, M., Konishi, M., Ohkido, I., Matsufuji, S. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  22. Factor V Leiden polymorphism modifies sepsis outcome: evidence from animal studies. Weiler, H., Kerlin, B., Lytle, M.C. Crit. Care Med. (2004) [Pubmed]
  23. A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures. Clément, Y., Launay, J.M., Bondoux, D., Venault, P., Martin, B., Young, J., Robel, P., Chapouthier, G. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1996) [Pubmed]
  24. Phenotypic heterogeneity and disease course in three murine strains with mutations in genes encoding for alpha 1 and beta glycine receptor subunits. Simon, E.S. Mov. Disord. (1997) [Pubmed]
  25. Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. Esau, C., Boes, M., Youn, H.D., Tatterson, L., Liu, J.O., Chen, J. J. Exp. Med. (2001) [Pubmed]
  26. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. Iglesias, A., Murga, M., Laresgoiti, U., Skoudy, A., Bernales, I., Fullaondo, A., Moreno, B., Lloreta, J., Field, S.J., Real, F.X., Zubiaga, A.M. J. Clin. Invest. (2004) [Pubmed]
  27. Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression. Kirchgessner, T.G., LeBoeuf, R.C., Langner, C.A., Zollman, S., Chang, C.H., Taylor, B.A., Schotz, M.C., Gordon, J.I., Lusis, A.J. J. Biol. Chem. (1989) [Pubmed]
  28. Toll-like receptor 4 plays an anti-HBV role in a murine model of acute hepatitis B virus expression. Chang, W.W., Su, I.J., Lai, M.D., Chang, W.T., Huang, W., Lei, H.Y. World J. Gastroenterol. (2005) [Pubmed]
  29. The ciliary neurotrophic factor and its receptor, CNTFR alpha. Sleeman, M.W., Anderson, K.D., Lambert, P.D., Yancopoulos, G.D., Wiegand, S.J. Pharmaceutica acta Helvetiae. (2000) [Pubmed]
  30. 28 K cholecalcin (CaBP) levels in abnormal cerebella: studies on mutant mice and harmaline- and 3-acetylpyridine-treated rats. Parkes, C.O., Mariani, J., Thomasset, M. Brain Res. (1985) [Pubmed]
  31. Chronic anti-ataxic actions of the novel thyrotropin-releasing hormone (TRH) analog, TA-0910, during and after repeated administration in Rolling mouse Nagoya: behavioral and pharmacokinetic studies. Kinoshita, K., Fukushima, T., Kodama, Y., Sugihara, J., Yamamura, M., Matsuoka, Y. Biol. Pharm. Bull. (1997) [Pubmed]
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