Disease relevance of Mice, Mutant Strains

• Analysis of this mutant strain of mouse is expected to provide valuable information on the pathogenesis of human type III tyrosinemia and can also serve as a useful system for studies on tyrosine metabolism [1].
• Traumatic brain injury causes delayed motor and cognitive impairment in a mutant mouse strain known to exhibit delayed Wallerian degeneration [2].
• The mutant mouse strains splotch-delayed (Pax3Sp-d) and curly tail (ct) develop neural tube defects (NTDs) in the lumbosacral region of the neuraxis [3].

Psychiatry related information on Mice, Mutant Strains

• The serologic lesion of the I-A mutant mouse strain, bm12, was investigated with the use of monoclonal anti-Iab antibodies and anti-idiotypic (Id) reagents produced against these antibodies [4].

High impact information on Mice, Mutant Strains

• A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology [5].
• The H-2 I-Ab mutant mouse strain bm12 differs from its strain of origin, C57BL/6 (H-2b), only in three amino acids in the I-A beta bm12 class II H-2 molecule [6].
• The lymphoid-independent nature of IL-4 action is supported by the analysis of mutant mouse strains with defined lymphocyte immunodeficiencies [7].
• To establish the role of E2F3 in vivo, we generated an E2f3 mutant mouse strain [8].
• A mutant mouse strain was generated by replacing the IL-2 gene with a cDNA encoding green fluorescent protein (GFP) [9].

Biological context of Mice, Mutant Strains

• The mutant mouse strain Mpv17 carries a retroviral insert in its genome which inactivates the Mpv17 gene [10].
• No difference in the size or abundance of POMC transcripts was seen in testes from mouse mutant strains in which spermatogenesis is arrested in early spermiogenesis [11].
• Splenic B cells and B cell blasts from the I-A mutant mouse strain B6.C-H-2bm12 were tested by serology with a series of new monoclonal anti-Iab antibodies [12].
• This suggests that all four genes are perinatally triggered at the level of similar elements in their transcriptional regulatory regions, a conclusion strengthened by the weak expression of the four genes that is seen in a mutant mouse strain (albino) that is deficient in some liver-specific transcription factors [13].
• The slow Wallerian degeneration mouse (C57BL/Wld(s)) is a mutant strain of mouse, with the unique phenotype of prolonged survival of the distal axon following axotomy [14].

Anatomical context of Mice, Mutant Strains

• T cell responses to select Ia determinants using the I-A mutant mouse strain B6.C-H-2bm12 [15].
• Observations in humans and, more recently, in several induced mutant mouse strains have provided important insights on how fat calories and lipids are partitioned to storage or energy production through the tissue-specific regulation of lipoprotein lipase in adipose tissue and muscle [16].
• The sPLA2 mRNA was expressed at very high levels in the BALB/c mouse small intestine, whereas in the small intestine of the sPLA2 mutant mouse strains, sPLA2 mRNA was undetectable [17].
• As a direct effect of these elevated mitochondrial activities, in both hepatic cells from mutant mouse strains and Hep G2 cells, adenosine 5'-triphosphate (ATP) levels significantly increased as the intracellular PP concentration was reduced [18].
• Tissue levels of BH4 and GTP-CH were also studied in mutant mouse strains having mutations in either pituitary or thyroid functions in order to examine further the role of these tissues in the regulation of the biosynthesis of this cofactor [19].

Associations of Mice, Mutant Strains with chemical compounds

• Feeding a diet supplemented with carbonyl iron resulted in a more than 5-fold reduction of (59)Fe absorption in both wild-type and mutant mouse strains [20].
• To study the regulatory mechanisms of intracellular Mg(2+) concentration ([Mg(2+)](i)) in renal tubular cells as well as in other cell types, we established a mutant strain of mouse renal cortical tubular cells that can grow in culture media with very high extracellular Mg(2+) concentrations ([Mg(2+)](o) > 100 mM: 101Mg-tolerant cells) [21].
• The mutant mouse strains were subjected to lethal doses of bacterial lipopolysaccharide [22].
• A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures [23].
• Three autosomal recessive mutant mouse strains with single-gene mutations affecting either the alpha 1 (spasmodic and oscillator) or beta (spastic) subunits of the glycine receptor were studied [24].

Gene context of Mice, Mutant Strains

• The role of these interactions under physiological conditions was investigated using a mutant mouse strain that expresses a truncated Cabin1 lacking the COOH-terminal calcineurin and MEF2 binding domains [25].
• Here we use mutant mouse strains to investigate the function of E2F1 and E2F2 in vivo [26].
• This indicates that combined deficiencies of LPL and hepatic lipase, observed in humans as well as in certain mutant strains of mice, do not result from focal disruptions of a cluster of lipase genes [27].
• TLR4 normal or mutant mouse strain was compared to investigate the possible role of TLR4 in acute HBV expression [28].
• The neuroprotective effects of CNTF have been demonstrated in a number of in vitro cell models as well as in vivo in mutant mouse strains which exhibit motor neuron degeneration [29].

Analytical, diagnostic and therapeutic context of Mice, Mutant Strains

• The cerebellar CaBP contents of 3-acetylpyridine- and harmaline-treated rats and 5 mutant mouse strains (Purkinje cell degeneration, reeler, weaver, staggerer and nervous) were measured using a specific radioimmunoassay [30].
• Anti-ataxic effects of TA-0910, a novel thyrotropin-releasing hormone analog, in mice of the ataxic mutant mouse strain Rolling mouse Nagoya (RMN) are sustained beyond its 2-week oral administration period (Kinoshita et al., Eur. J. Pharmacol., 274, 65-72, 1995) [31].

References