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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo.

It was previously shown that circulating levels of leptin and apolipoprotein M (apoM) correlate to each other. In this study, we examined whether plasma leptin and leptin-receptors are of importance for apoM expression in vivo. It was found that in both liver and kidney, expression of apoM was significantly lower in leptin deficient ob/ob mice and in leptin-receptor deficient db/db mice than in control mice. Furthermore, leptin administration (0.5 or 1.5 microg/g body weight) significantly increased plasma apoM levels and apoM mRNA levels in liver and in kidney in ob/ob mice. We conclude that both leptin and leptin-receptor are essential for the apoM expression, indicating that leptin is physiologically regulating apoM synthesis in vivo.[1]

References

  1. Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo. Xu, N., Nilsson-Ehle, P., Hurtig, M., Ahrén, B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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