Gene Review:
Lepr - leptin receptor
Mus musculus
Synonyms:
B219, Db, LEP-R, LEPROT, Leprb, ...
Gao,
Mezei,
Nie,
Rao,
Choi,
Bechmann,
Leranth,
Toran-Allerand,
Priest,
Roberts,
Gao,
Mobbs,
Shulman,
Diano,
Horvath,
Udagawa,
Nimura,
Otani,
Sleeman,
Garcia,
Liu,
Murray,
Malinova,
Moncrieffe,
Yancopoulos,
Wiegand,
Kim,
Taylor,
Young,
Karst,
Nishina,
Naggert,
Korner,
Savontaus,
Chua,
Leibel,
Wardlaw,
Garris,
Garris,
Berger,
Tanen,
Elbrecht,
Hermanowski-Vosatka,
Moller,
Wright,
Thieringer,
- New leptin receptor mutations in mice: Lepr(db-rtnd), Lepr(db-dmpg) and Lepr(db-rlpy). Kim, J.H., Taylor, P.N., Young, D., Karst, S.Y., Nishina, P.M., Naggert, J.K. J. Nutr. (2003)
- An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. McMinn, J.E., Liu, S.M., Dragatsis, I., Dietrich, P., Ludwig, T., Eiden, S., Chua, S.C. Mamm. Genome (2004)
- Minor gene effect of leptin receptor variant on the body weight in KK/Ta mice. Gohda, T., Tanimoto, M., Kaneko, S., Shibata, T., Funabiki, K., Horikoshi, S., Tomino, Y. Diabetes, obesity & metabolism. (2006)
- Role of leptin and melanocortin signaling in uremia-associated cachexia. Cheung, W., Yu, P.X., Little, B.M., Cone, R.D., Marks, D.L., Mak, R.H. J. Clin. Invest. (2005)
- Selective deletion of leptin receptor in neurons leads to obesity. Cohen, P., Zhao, C., Cai, X., Montez, J.M., Rohani, S.C., Feinstein, P., Mombaerts, P., Friedman, J.M. J. Clin. Invest. (2001)
- LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Bates, S.H., Dundon, T.A., Seifert, M., Carlson, M., Maratos-Flier, E., Myers, M.G. Diabetes (2004)
- Induction of leptin receptor expression in the liver by leptin and food deprivation. Cohen, P., Yang, G., Yu, X., Soukas, A.A., Wolfish, C.S., Friedman, J.M., Li, C. J. Biol. Chem. (2005)
- Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Wang, Y.X., Lee, C.H., Tiep, S., Yu, R.T., Ham, J., Kang, H., Evans, R.M. Cell (2003)
- Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Martinez-Botas, J., Anderson, J.B., Tessier, D., Lapillonne, A., Chang, B.H., Quast, M.J., Gorenstein, D., Chen, K.H., Chan, L. Nat. Genet. (2000)
- Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A.F., Beil, F.T., Shen, J., Vinson, C., Rueger, J.M., Karsenty, G. Cell (2000)
- Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Chen, H., Charlat, O., Tartaglia, L.A., Woolf, E.A., Weng, X., Ellis, S.J., Lakey, N.D., Culpepper, J., Moore, K.J., Breitbart, R.E., Duyk, G.M., Tepper, R.I., Morgenstern, J.P. Cell (1996)
- Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo. Kim, J.G., Baggio, L.L., Bridon, D.P., Castaigne, J.P., Robitaille, M.F., Jetté, L., Benquet, C., Drucker, D.J. Diabetes (2003)
- Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice. Chua, S.C., Liu, S.M., Li, Q., Sun, A., DeNino, W.F., Heymsfield, S.B., Guo, X.E. Am. J. Physiol. Endocrinol. Metab. (2004)
- Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Sleeman, M.W., Garcia, K., Liu, R., Murray, J.D., Malinova, L., Moncrieffe, M., Yancopoulos, G.D., Wiegand, S.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia. Garris, D.R., Garris, B.L. Cell Tissue Res. (2005)
- High leptin level is accompanied with decreased long leptin receptor transcript in histamine deficient transgenic mice. Hegyi, K., Fülöp, K.A., Kovács, K.J., Falus, A., Tóth, S. Immunol. Lett. (2004)
- Identification and expression cloning of a leptin receptor, OB-R. Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G.J., Campfield, L.A., Clark, F.T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K.J., Smutko, J.S., Mays, G.G., Wool, E.A., Monroe, C.A., Tepper, R.I. Cell (1995)
- Abnormal splicing of the leptin receptor in diabetic mice. Lee, G.H., Proenca, R., Montez, J.M., Carroll, K.M., Darvishzadeh, J.G., Lee, J.I., Friedman, J.M. Nature (1996)
- STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Bates, S.H., Stearns, W.H., Dundon, T.A., Schubert, M., Tso, A.W., Wang, Y., Banks, A.S., Lavery, H.J., Haq, A.K., Maratos-Flier, E., Neel, B.G., Schwartz, M.W., Myers, M.G. Nature (2003)
- Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Vaisse, C., Halaas, J.L., Horvath, C.M., Darnell, J.E., Stoffel, M., Friedman, J.M. Nat. Genet. (1996)
- Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Gao, Q., Mezei, G., Nie, Y., Rao, Y., Choi, C.S., Bechmann, I., Leranth, C., Toran-Allerand, D., Priest, C.A., Roberts, J.L., Gao, X.B., Mobbs, C., Shulman, G.I., Diano, S., Horvath, T.L. Nat. Med. (2007)
- Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Kieffer, T.J., Heller, R.S., Leech, C.A., Holz, G.G., Habener, J.F. Diabetes (1997)
- Altering dietary protein type and quantity reduces urinary albumin excretion without affecting plasma glucose concentrations in BKS.cg-m +Lepr db/+Lepr db (db/db) mice. Teixeira, S.R., Tappenden, K.A., Erdman, J.W. J. Nutr. (2003)
- TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nakagawa, Y., Shimano, H., Yoshikawa, T., Ide, T., Tamura, M., Furusawa, M., Yamamoto, T., Inoue, N., Matsuzaka, T., Takahashi, A., Hasty, A.H., Suzuki, H., Sone, H., Toyoshima, H., Yahagi, N., Yamada, N. Nat. Med. (2006)
- Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice. Siegmund, B., Sennello, J.A., Jones-Carson, J., Gamboni-Robertson, F., Lehr, H.A., Batra, A., Fedke, I., Zeitz, M., Fantuzzi, G. Gut (2004)
- Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain. Itateyama, E., Chiba, S., Sakata, T., Yoshimatsu, H. Exp. Biol. Med. (Maywood) (2003)
- Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity. Berger, J., Tanen, M., Elbrecht, A., Hermanowski-Vosatka, A., Moller, D.E., Wright, S.D., Thieringer, R. J. Biol. Chem. (2001)
- The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Ghilardi, N., Skoda, R.C. Mol. Endocrinol. (1997)
- The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. V. Interaction between the db gene and hepatic sex steroid sulfotransferases correlates with gender-dependent susceptibility to hyperglycemia. Leiter, E.H., Chapman, H.D., Coleman, D.L. Endocrinology (1989)
- Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways. O'Rourke, L., Yeaman, S.J., Shepherd, P.R. Diabetes (2001)
- PTP1B regulates leptin signal transduction in vivo. Zabolotny, J.M., Bence-Hanulec, K.K., Stricker-Krongrad, A., Haj, F., Wang, Y., Minokoshi, Y., Kim, Y.B., Elmquist, J.K., Tartaglia, L.A., Kahn, B.B., Neel, B.G. Dev. Cell (2002)
- In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Kim, Y.B., Uotani, S., Pierroz, D.D., Flier, J.S., Kahn, B.B. Endocrinology (2000)
- Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. M??nzberg, H., Jobst, E.E., Bates, S.H., Jones, J., Villanueva, E., Leshan, R., Bj??rnholm, M., Elmquist, J., Sleeman, M., Cowley, M.A., Myers, M.G. J. Neurosci. (2007)
- Identification of SOCS-3 as a potential mediator of central leptin resistance. Bjørbaek, C., Elmquist, J.K., Frantz, J.D., Shoelson, S.E., Flier, J.S. Mol. Cell (1998)
- Localization of leptin receptor mRNA expression in mouse brain. Huang, X.F., Koutcherov, I., Lin, S., Wang, H.Q., Storlien, L. Neuroreport (1996)
- Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. Mercer, J.G., Moar, K.M., Rayner, D.V., Trayhurn, P., Hoggard, N. FEBS Lett. (1997)
- Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus. Korner, J., Savontaus, E., Chua, S.C., Leibel, R.L., Wardlaw, S.L. J. Neuroendocrinol. (2001)
- Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Lin, S., Storlien, L.H., Huang, X.F. Brain Res. (2000)
- Leptin receptor-mediated regulation of cholinergic neurotransmitter phenotype in cells of central nervous system origin. Di Marco, A., Demartis, A., Gloaguen, I., Lazzaro, D., Delmastro, P., Ciliberto, G., Laufer, R. Eur. J. Biochem. (2000)
- Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo. Xu, N., Nilsson-Ehle, P., Hurtig, M., Ahrén, B. Biochem. Biophys. Res. Commun. (2004)
- Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse. Igel, M., Becker, W., Herberg, L., Joost, H.G. Endocrinology (1997)
- Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus--relationship with NPY neurones. Håkansson, M.L., Hulting, A.L., Meister, B. Neuroreport (1996)
- Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene. Horev, G., Einat, P., Aharoni, T., Eshdat, Y., Friedman-Einat, M. Mol. Cell. Endocrinol. (2000)
- Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex. Udagawa, J., Nimura, M., Otani, H. Neuro Endocrinol. Lett. (2006)