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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Intestinal pseudo-obstruction following the use of enteral charcoal and sorbitol and mechanical ventilation with papaveretum sedation for theophylline poisoning.

We report 2 cases of intestinal pseudo-obstruction, 1 fatal, which developed following the use of enteral activated charcoal with sorbitol, and mechanical ventilation with papaveretum ('Omnopon') sedation for the treatment of severe theophylline self-poisoning. While mechanical intestinal obstruction may rarely complicate the use of enteral activated charcoal, pseudo-obstruction has not been previously described. Causal mechanisms and prophylaxis are discussed, highlighting a possible interaction between theophylline and papaveretum, and the dangers of multidose enteral charcoal with sorbitol in this context.[1]

References

  1. Intestinal pseudo-obstruction following the use of enteral charcoal and sorbitol and mechanical ventilation with papaveretum sedation for theophylline poisoning. Longdon, P., Henderson, A. Drug safety : an international journal of medical toxicology and drug experience. (1992) [Pubmed]
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