Histochemical characterization of skeletal muscles in rats with photochemically-induced stroke.
PRIMARY OBJECTIVE: The aim of this study was to assess skeletal muscle showing a complete functional recovery after induction of pan-necrotic lesions in the right sensorimotor cortex in rats. RESEARCH DESIGN AND METHODS: A focal lesion of the right sensorimotor cortex was induced photochemically. Rats were divided into three groups; the sham-operated group (CON), Stroke (RB) and Stroke plus severed right sciatic nerve ( RBD). MAIN OUTCOMES AND RESULTS: All RB rats showed complete functional recovery in the beam-walking test within 10 days. The score of CON rats was 7 for 21 days. The wet weight of the soleus muscle (SOL) only in the RB and RBD was significantly greater than in the CON. The cross-sectional area of type I fibres was increased in SOL. CONCLUSIONS: It was concluded that the functional recovery was mainly due to increased wet weight and cross-sectional area of type I SOL fibres, which probably reflected the functional reorganization and neuromodulation in the non-damaged contralateral sensorimotor cortex and ipsilateral sensorimotor cortex lateral to the lesion identified in a previous study.[1]References
- Histochemical characterization of skeletal muscles in rats with photochemically-induced stroke. Abo, M., Miyano, S., Eun, S.S., Yamauchi, H. Brain injury : [BI]. (2004) [Pubmed]
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