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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Functional effects of variants of the RNA chaperone Hfq.

The ring-shaped RNA chaperone Hfq has recently received much attention owing to its multiple roles in RNA metabolism. In this study we have performed a mutational analysis of the Escherichia coli hfq gene, and have studied the effects of amino acid substitutions at several positions in the Hfq protein as well as of C-terminal truncations on its role in phage Qbeta replication, in repression of a target mRNA, and on the stability of the small regulatory RNA DsrA. These functional studies provided insights into the interaction of Hfq with RNA and suggested a role for the C-terminus of Hfq in DsrA stability.[1]

References

  1. Functional effects of variants of the RNA chaperone Hfq. Sonnleitner, E., Napetschnig, J., Afonyushkin, T., Ecker, K., Vecerek, B., Moll, I., Kaberdin, V.R., Bläsi, U. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
 
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